Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …

The epithelial cell–derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25
are central regulators of type 2 immunity, which drives a broad array of allergic responses …

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …

The intestine harbors a large population of resident eosinophils, yet the function of intestinal
eosinophils has not been explored. Flow cytometry and whole-mount imaging identified …

Lungs are one of the main sites of breast cancer metastasis. The metastatic
microenvironment is essential to facilitate growth of disseminated tumor cells. Cancer …

Abstract Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory
responses following tissue damage or infection and is a promising target for treatment of …

Myelofibrosis (MF) is a myeloproliferative disorder that exhibits considerable biological and
clinical heterogeneity. At the two ends of the disease spectrum are the myelodepletive or …

Abstract Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines and was initially
described as an IFN-γ-inducing factor derived from anti-CD3-stimulated T-helper (Th) 1 …

Retinal neurodegeneration is predominantly reported as the apoptosis or impaired function
of the photoreceptors. Retinal degeneration is a major causative factor of irreversible vision …

NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate
the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a …