Insulin-like growth factor-binding proteins (IGFBPs) 1–6 bind IGFs but not insulin with high
affinity. They were initially identified as serum carriers and passive inhibitors of IGF actions …

The IGF-binding protein family contains six members that share significant structural
homology. Their principal function is to regulate the actions of IGF1 and IGF2. These …

Cannabidiol (CBD), a phytochemical derived from Cannabis sativa L., has been
demonstrated to exhibit promising anti-tumor properties in multiple cancer types. However …

Mechanistic target of rapamycin (mTOR) signaling functions as a central regulator of cellular
metabolism, growth, and survival in response to hormones, growth factors, nutrients, energy …

Recent findings from human and animal studies indicate that maternal undernutrition or
overnutrition affects covalent modifications of the fetal genome and its associated histones …

Fetal growth restriction (FGR) increases the risk of perinatal complications and predisposes
the infant to developing metabolic, cardiovascular, and neurological diseases in childhood …

Fetal growth restriction (FGR) increases the risk for perinatal complications and predisposes
the infant to diabetes and cardiovascular disease later in life. No treatment for FGR is …

Intrauterine growth restriction (IUGR) confers heritable alterations in DNA methylation,
rendering risk of adult metabolic syndrome (MetS). Because CpG methylation is coupled to …

The mechanisms mediating the restricted growth in intrauterine growth restriction (IUGR)
remain to be fully established. Mechanistic target of rapamycin (mTOR) signaling functions …

In fetal growth restriction (FGR), fetal growth is limited by reduced nutrient and oxygen
supply. Insulin-like growth factor I (IGF-I) is a key regulator of fetal growth and IGF binding …