Cyclic nucleotide-binding domain (CNBD) channels are a family of ion channels in the
voltage-gated K+ channel superfamily that play crucial roles in many physiological …

Two decades of research have proven the relevance of ion channel expression for tumor
progression in virtually every indication, and it has become clear that inhibition of specific …

The KCNH voltage-dependent potassium channels (ether-à-go-go, EAG; EAG-related gene,
ERG; EAG-like channels, ELK) are important regulators of cellular excitability,, and have key …

Aims More than one-third of type 2 long QT syndrome (LQT2) patients carry KCNH2 non-
missense variants that can result in haploinsufficiency (HI), leading to mechanistic loss-of …

Binding of 3′, 5′-cyclic adenosine monophosphate (cAMP) to hyperpolarization-activated
cyclic nucleotide-gated (HCN) ion channels regulates their gating. cAMP binds to a …

Plant voltage-gated K+ channels have been referred to as “plant Shakers” in reference to
animal Shaker channels, the first K+ channels identified. Recent advances in our knowledge …

Protein-folding diseases are an ongoing medical challenge. Many diseases within this
group are genetically determined, and have no known cure. Among the examples in which …

The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac
electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology …

Cyclic nucleotide-modulated ion channels are molecular pores that mediate the passage of
ions across the cell membrane in response to cAMP or GMP. Structural insight into this class …

Fertilization is exceptionally complex and, depending on the species, happens in entirely
different environments. External fertilizers in aquatic habitats, like marine invertebrates or …