Targeting PI3K/Akt/mTOR signaling pathway in the treatment of prostate cancer radioresistance
L Chang, PH Graham, J Ni, J Hao, J Bucci… - Critical reviews in …, 2015 - Elsevier
Abstract The phosphatidylinositol-3-kinase/Akt and the mammalian target of rapamycin
(PI3K/Akt/mTOR) pathway is one of the most frequently activated signaling pathways in …
(PI3K/Akt/mTOR) pathway is one of the most frequently activated signaling pathways in …
[HTML][HTML] PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy …
L Chang, PH Graham, J Hao, J Ni, J Bucci… - Cell death & …, 2014 - nature.com
Abstract The PI3K/Akt/mTOR pathway has a central role in cancer metastasis and
radiotherapy. To develop effective therapeutics to improve radiosensitivity, understanding …
radiotherapy. To develop effective therapeutics to improve radiosensitivity, understanding …
[HTML][HTML] Drivers of radioresistance in prostate cancer
L King, N Bernaitis, D Christie… - Journal of Clinical …, 2022 - mdpi.com
Prostate cancer (PCa) is the second most commonly diagnosed cancer worldwide.
Radiotherapy remains one of the first-line treatments in localised disease and may be used …
Radiotherapy remains one of the first-line treatments in localised disease and may be used …
[HTML][HTML] Five-year biochemical results, toxicity, and patient-reported quality of life after delivery of dose-escalated image guided proton therapy for prostate cancer
C Bryant, TL Smith, RH Henderson, BS Hoppe… - International Journal of …, 2016 - Elsevier
Purpose To report clinical outcomes in patients treated with image guided proton therapy
(PT) for localized prostate cancer. Methods and Materials The medical records of 1327 men …
(PT) for localized prostate cancer. Methods and Materials The medical records of 1327 men …
[HTML][HTML] Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse
JC Cheng, A Bai, TH Beckham… - The Journal of …, 2013 - Am Soc Clin Investig
Escape of prostate cancer (PCa) cells from ionizing radiation–induced (IR-induced) killing
leads to disease progression and cancer relapse. The influence of sphingolipids, such as …
leads to disease progression and cancer relapse. The influence of sphingolipids, such as …
Five-year outcomes from 3 prospective trials of image-guided proton therapy for prostate cancer
NP Mendenhall, BS Hoppe, RC Nichols… - International Journal of …, 2014 - Elsevier
Purpose To report 5-year clinical outcomes of 3 prospective trials of image-guided proton
therapy for prostate cancer. Methods and Materials A total of 211 prostate cancer patients …
therapy for prostate cancer. Methods and Materials A total of 211 prostate cancer patients …
Salvage high‐intensity focused ultrasound (HIFU) for locally recurrent prostate cancer after failed radiation therapy: Multi‐institutional analysis of 418 patients
S Crouzet, A Blana, FJ Murat, G Pasticier… - BJU …, 2017 - Wiley Online Library
Objective To report the oncological outcome of salvage high‐intensity focused ultrasound (S‐
HIFU) for locally recurrent prostate cancer after external beam radiotherapy (EBRT) from a …
HIFU) for locally recurrent prostate cancer after external beam radiotherapy (EBRT) from a …
Improved outcomes with advancements in high intensity focused ultrasound devices for the treatment of localized prostate cancer
T Uchida, T Tomonaga, H Kim, M Nakano… - The Journal of …, 2015 - auajournals.org
Purpose: We evaluated the association between long-term clinical outcomes and morbidity
with high intensity focused ultrasound. Materials and Methods: We included patients with …
with high intensity focused ultrasound. Materials and Methods: We included patients with …
[HTML][HTML] Biochemical recurrence prediction after radiotherapy for prostate cancer with T2w magnetic resonance imaging radiomic features
Background and purpose High-risk prostate cancer patients are frequently treated with
external-beam radiotherapy (EBRT). Of all patients receiving EBRT, 15–35% will experience …
external-beam radiotherapy (EBRT). Of all patients receiving EBRT, 15–35% will experience …
[HTML][HTML] Overexpression of AKR1C3 significantly enhances human prostate cancer cells resistance to radiation
SQ Sun, X Gu, XS Gao, Y Li, H Yu, W Xiong, H Yu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Aldo-keto reductase 1C3 (AKR1C3) is an enzyme involved in prostaglandins
metabolism. Studies suggest that AKR1C3 has a pivotal role in the radioresistance of …
metabolism. Studies suggest that AKR1C3 has a pivotal role in the radioresistance of …