Pathway analysis has become the first choice for gaining insight into the underlying biology
of differentially expressed genes and proteins, as it reduces complexity and has increased …

Most of the published quantitative models in biology are lost for the community because they
are either not made available or they are insufficiently characterized to allow them to be …

Abstract The Reactome Knowledgebase (https://reactome. org), an Elixir and GCBR core
biological data resource, provides manually curated molecular details of a broad range of …

A full description of a protein's function requires knowledge of all partner proteins with which
it specifically associates. From a functional perspective,'association'can mean direct physical …

Abstract Reactome, located at http://www. reactome. org is a curated, peer-reviewed
resource of human biological processes. Given the genetic makeup of an organism, the …

A number of large-scale efforts are underway to define the relationships between genes and
proteins in various species. But, few attempts have been made to systematically classify all …

Background MicroRNAs are a class of small RNAs known to regulate gene expression at the
transcript level, the protein level, or both. Since microRNA binding is sequence-based but …

Genetic studies are traditionally based on single-gene analysis. The use of these analyses
can pose tremendous challenges for elucidating complicated genetic interplays involved in …

Emerging evidence indicates that gene products implicated in human cancers often cluster
together in “hot spots” in protein-protein interaction (PPI) networks. Additionally, small sub …

Motivation: Many areas of modern biology are concerned with the management, storage,
visualization, comparison and analysis of networks, but no appropriate query language for …