Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

The process of bone remodeling is the result of the regulated balance between bone cell
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …

Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

With increasing life expectations, more and more patients suffer from fractures either
induced by intensive sports or other bone-related diseases. The balance between …

Bones as an alive organ consist of about 70% mineral and 30% organic component. About
200 million people are suffering from osteopenia and osteoporosis around the world. There …

Mechanical loading, such as caused by exercise, stimulates bone formation by osteoblasts
and increases bone strength, but the mechanisms are poorly understood. Osteocytes reside …

As direct effector cells for osteogenesis, osteoblastic cells are commonly used for evaluating
the in vitro osteogenic capacity of bone biomaterials, and the traditional biological principle …

Osteocytes play a critical role in maintaining bone homeostasis and in regulating skeletal
response to hormones and mechanical loading. Substantial evidence have demonstrated …

Trabecular bone is a highly porous, heterogeneous, and anisotropic material which can be
found at the epiphyses of long bones and in the vertebral bodies. Studying the mechanical …

While blood vessels play important roles in bone homeostasis and repair, fundamental
aspects of vascular function in the skeletal system remain poorly understood. Here we show …