Chemical protein modification has emerged as an invaluable tool for the development of
modified proteins. The complementary use of both genetic and chemical methods has …

Proteins are the major component of the living cell. They play crucial roles in the
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …

Bioconjugation technologies have revolutionized the practice of biology and medicine by
allowing access to novel biomolecular scaffolds. New methods for residue-selective …

Abstract Site-Directed Spin Labelling (SDSL) technique is based on the attachment of a
paramagnetic label onto a specific position of a protein (or other bio-molecules) and the …

Electron paramagnetic resonance (EPR) spectroscopy is a powerful and widely used
technique for studying structure and dynamics of biomolecules under bio-orthogonal …

Approaching protein structural dynamics and protein–protein interactions in the cellular
environment is a fundamental challenge. Owing to its absolute sensitivity and to its …

Exploring the structure and dynamics of biomolecules in the context of their intracellular
environment has become the ultimate challenge for structural biology. As the cellular …

Intrinsically disordered proteins (IDPs) possess the property of inherent flexibility and can be
distinguished from other proteins in terms of lack of any fixed structure. Such dynamic …

The study of how the intracellular medium influences protein structural dynamics and protein–
protein interactions is a captivating area of research for scientists aiming to comprehend …

Exciting new technological developments have pushed the boundaries of structural biology,
and have enabled studies of biological macromolecules and assemblies that would have …