RNAs fold into 3D structures that range from simple helical elements to complex tertiary
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …

With rapid advances in computer algorithms and hardware, fast and accurate virtual
screening has led to a drastic acceleration in selecting potent small molecules as drug …

Summary 7SK is a conserved noncoding RNA that regulates transcription by sequestering
the transcription factor P-TEFb. 7SK function entails complex changes in RNA structure, but …

RNA dynamics play a fundamental role in many cellular functions. However, there is no
general framework to describe these complex processes, which typically consist of many …

Riboswitches control gene expression through ligand-dependent structural rearrangements
of the sensing aptamer domain. However, we found that the Bacillus cereus fluoride …

RNA structure and dynamics are critical to biological function. However, strategies for
determining RNA structure in vivo are limited, with established chemical probing and newer …

RNA secondary structure prediction is widely used for developing hypotheses about the
structures of RNA sequences, and structure can provide insight about RNA function. The …

In synthetic biology, metabolic engineering, and gene therapy, there is a strong demand for
orthogonal or externally controlled regulation of gene expression. Here, RNA-based …

Cell-free protein synthesis assays have become a valuable tool to understand
transcriptional and translational processes. Here, we established a fluorescence-based …

RNA utilizes many different mechanisms to control gene expression. Among the regulatory
elements that respond to external stimuli, riboswitches are a prominent and elegant …