Despite its importance, understanding the early phases of human development has been
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …

The emergence of form and function during mammalian embryogenesis is a complex
process that involves multiple regulatory levels. The foundations of the body plan are laid …

Early human embryonic development involves extensive lineage diversification, cell-fate
specification and tissue patterning. Despite its basic and clinical importance, early human …

Our understanding of how human embryos develop before gastrulation, including spatial
self-organization and cell type ontogeny, remains limited by available two-dimensional …

Understanding lineage specification during human pre-implantation development is a
gateway to improving assisted reproductive technologies and stem cell research. Here we …

Implantation is a milestone event during mammalian embryogenesis. Implantation failure is
a considerable cause of early pregnancy loss in humans. Owing to the difficulty of obtaining …

Embryonic stem cells can be incorporated into the developing embryo and its germ line, but,
when cultured alone, their ability to generate embryonic structures is restricted. They can …

Dynamic pluripotent stem cell (PSC) states are in vitro adaptations of pluripotency
continuum in vivo. Previous studies have generated a number of PSCs with distinct …

Recently, several studies using cultures of human embryos together with single-cell RNA-
seq analyses have revealed differences between humans and mice, necessitating the study …

Mammalian embryos sequentially differentiate into trophectoderm and an inner cell mass,
the latter of which differentiates into primitive endoderm and epiblast. Trophoblast stem (TS) …