Central precocious puberty results from the premature activation of the hypothalamic-
pituitary-gonadal axis. It mimics physiological pubertal development, although at an …

The classic definition of precocious sexual maturation is the development of secondary
sexual characteristics before 8 years of age in girls and before 9 years of age in boys. It is …

Gonadotropin-dependent, or central, precocious puberty is caused by early maturation of the
hypothalamic–pituitary–gonadal axis. In girls, this condition is most often idiopathic …

Context: Determining the etiology of delayed puberty during initial evaluation can be
challenging. Specifically, clinicians often cannot distinguish constitutional delay of growth …

Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain
challenging due to lack of standardization. The aim of this revision was to address the …

Management and outcome of central precocious puberty Page 1 Clinical Endocrinology (2002)
56, 129–148 © 2002 Blackwell Science Ltd 129 Blackwell Science Ltd Review Treatment of …

Context: Recently, new methodologies have been applied to commercial
immunofluorometric (IFMA) and immunochemiluminometric (ICMA) LH and FSH assays …

Context: Loss-of-function mutations in makorin ring finger 3 (MKRN3), an imprinted gene
located on the long arm of chromosome 15, have been recognized recently as a cause of …

OBJECTIVE. Using basal specimens from original gonadotropin radioimmunoassays, it was
not possible to differentiate prepuberty from puberty hence gonadotropin-releasing hormone …

Precocious puberty is defined as the development of secondary sexual characteristics
before the age of 8 years in girls and 9 years in boys. Gonadotropin-dependent precocious …