Nuclear receptors (NRs) are ligand-regulated transcription factors that regulate metabolism,
development and immunity. The NR superfamily is one of the major classes of drug targets …

In mammals, three major oxygenases, cyclooxygenases (COXs), lipoxygenases (LOXs), and
cytochrome P450 (CYP450), generate an assortment of unique lipid mediators (oxylipins) …

Pulmonary arterial hypertension (PAH) is a progressive disease of distal pulmonary arteries
in which patients suffer from elevated pulmonary arterial pressure, extensive vascular …

Peroxisome proliferator-activated receptors (PPARs) are members of a superfamily of
nuclear transcription factors. They are involved in mediating numerous physiological effects …

Peroxisome proliferator-activator receptors α/δ (PPARα/δ) are regarded as potential
therapeutic targets for nonalcoholic steatohepatitis (NASH). However, PPARα/δ dual agonist …

Complex molecular and cellular mechanisms are involved in the pathway of liver fibrosis.
Activation and transformation of hepatic stellate cells (HSCs) are considered the two main …

Our previous study showed that α-lactalbumin (α-LA) has a regulatory effect on lipid
metabolism in obese mice. In this study, we performed simulated gastrointestinal digestion …

Cardiac hypertrophy and associated heart fibrosis remain a major cause of death worldwide.
Phytochemicals have gained attention as alternative therapeutics for managing …

Specific metabolic pathways are activated by different nutrients to adapt the organism to
available resources. Although essential, these mechanisms are incompletely defined. Here …

The selective PPARα modulator (SPPARMα) is expected to medicate dyslipidemia with
minimizing adverse effects. Recently, pemafibrate was screened from the ligand library as …