Strategic approaches to improvise peptide drugs as next generation therapeutics

P Barman, S Joshi, S Sharma, S Preet… - International journal of …, 2023 - Springer
In recent years, the occurrence of a wide variety of drug-resistant diseases has led to an
increase in interest in alternate therapies. Peptide-based drugs as an alternate therapy hold …

Recent advances: peptides and self-assembled peptide-nanosystems for antimicrobial therapy and diagnosis

P Zou, WT Chen, T Sun, Y Gao, LL Li, H Wang - Biomaterials Science, 2020 - pubs.rsc.org
Bacterial infections, especially the refractory treatment of drug-resistant bacteria, are one of
the greatest threats to human health. During the past decades, biomedical nanomaterials …

Antimicrobial peptides as anti-infective agents in pre-post-antibiotic era?

T Rončević, J Puizina, A Tossi - International journal of molecular …, 2019 - mdpi.com
Resistance to antibiotics is one of the main current threats to human health and every year
multi-drug resistant bacteria are infecting millions of people worldwide, with many dying as a …

Role and modulation of the secondary structure of antimicrobial peptides to improve selectivity

Y Liang, X Zhang, Y Yuan, Y Bao, M Xiong - Biomaterials Science, 2020 - pubs.rsc.org
Since the development of bacterial resistance, the decreasing effectiveness of antibiotics is
becoming one of the most critical problems worldwide. Novel antibacterial agents are …

Anisaxins, helical antimicrobial peptides from marine parasites, kill resistant bacteria by lipid extraction and membrane disruption

T Rončević, M Gerdol, M Mardirossian, M Maleš… - Acta biomaterialia, 2022 - Elsevier
An infecting and propagating parasite relies on its innate defense system to evade the host's
immune response and to survive challenges from commensal bacteria. More so for the …

Cationic amphiphilic peptides: Synthetic antimicrobial agents inspired by nature

R Kundu - ChemMedChem, 2020 - Wiley Online Library
Antimicrobial peptides are ubiquitous in multicellular organisms and have served as
defense mechanisms for their successful evolution and throughout their life cycle. These …

Potent and broad-spectrum antimicrobial activity of analogs from the scorpion peptide stigmurin

B Amorim-Carmo, A Daniele-Silva… - International journal of …, 2019 - mdpi.com
Scorpion venom constitutes a rich source of biologically active compounds with high
potential for therapeutic and biotechnological applications that can be used as prototypes for …

The potential of modified and multimeric antimicrobial peptide materials as superbug killers

T Matthyssen, W Li, JA Holden, JC Lenzo… - Frontiers in …, 2022 - frontiersin.org
Antimicrobial peptides (AMPs) are found in nearly all living organisms, show broad spectrum
antibacterial activity, and can modulate the immune system. Furthermore, they have a very …

Glycine‐replaced epinecidin‐1 variant bestows better stability and stronger antimicrobial activity against a range of nosocomial pathogenic bacteria

S Jeyarajan, AS Peter, S Ranjith… - Biotechnology and …, 2024 - Wiley Online Library
Abstract Epinecidin‐1 (epi‐1), an antimicrobial peptide first identified in marine grouper fish,
has multifunctional bioactivities. The present study aims to improve its therapeutic potential …

Discovery of novel quaternary ammonium compounds based on quinuclidine-3-ol as new potential antimicrobial candidates

L Bazina, A Maravić, L Krce, B Soldo, R Odžak… - European journal of …, 2019 - Elsevier
Quaternary ammonium compounds (QACs) are amphiphilic molecules displaying a broad-
spectrum of antibacterial activity. QACs are commonly used antiseptics in industrial, home …