Preclinical studies of the T cell growth factor activity of IL-2 resulted in this cytokine
becoming the first immunotherapy to be approved nearly 30 years ago by the US Food and …

Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …

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Cytokines have pivotal roles in immunity, making them attractive as therapeutics for a variety
of immune-related disorders. However, the widespread clinical use of cytokines has been …

Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …

Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …

Immune homeostasis is heavily dependent on the action of regulatory T cells (Tregs) which
act to suppress the activation of many immune cell types including autoreactive conventional …

Regulatory T (Treg) cells ensure tolerance against self-antigens, limit excessive
inflammation, and support tissue repair processes. Therefore, Treg cells are currently …

Engineered regulatory T (Treg) cells have emerged as precision therapeutics aimed at
inducing immune tolerance while reducing the risks associated with generalized …

Graft versus host disease (GVHD) is a common complication and the leading cause of
morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT) …