Summary Sporadic Creutzfeldt-Jakob disease is a fatal neurodegenerative disease caused
by misfolded prion proteins (PrP Sc). Effective therapeutics are currently not available and …

The most definitive classification systems for dementia are based on the underlying
pathology which, in turn, is categorized largely according to the observed accumulation of …

Human prion diseases can be sporadic, inherited, or acquired by infection. Distinct clinical
and pathological characteristics separate sporadic diseases into three phenotypes …

Objective Several prion amplification systems have been proposed for detection of prions in
cerebrospinal fluid (CSF), most recently, the measurements of prion seeding activity with …

Abstract Purpose of Review: This article presents an update on the clinical aspects of human
prion disease, including the wide spectrum of their presentations. Recent Findings: Prion …

The differential diagnosis of Creutzfeldt-Jakob disease (CJD) from other, sometimes
treatable, neurological disorders is challenging, owing to the wide phenotypic heterogeneity …

Objective To present the National Prion Disease Pathology Surveillance Center's
(NPDPSC's) experience using CSF real-time quaking-induced conversion (RT-QuIC) as a …

Abstract Sporadic Creutzfeldt–Jakob disease (CJD), the most common human prion
disease, is generally regarded as a spontaneous neurodegenerative illness, arising either …

Prion diseases are a phenotypically diverse set of disorders characterized by protease-
resistant abnormally shaped proteins known as prions. There are three main groups of prion …

While cerebrospinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are
established and partly included in the diagnostic criteria, no blood biomarkers are available …