Mast cells have crucial roles in allergic and other inflammatory diseases. Preclinical
approaches provide circumstantial evidence for mast cell involvement in many diseases, but …

Sialic acid–binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of
white blood cells of the immune system and play critical roles in immune cell signaling …

This update on chronic urticaria (CU) focuses on the prevalence and pathogenesis of
chronic spontaneous urticaria (CSU), the expanding spectrum of patient-reported outcome …

Mast cells are unique tissue-resident immune cells of the myeloid lineage that have long
been implicated in the pathogenesis of allergic and autoimmune disorders. More recently …

Eosinophils can regulate local immune and inflammatory responses, and their accumulation
in the blood and tissue is associated with several inflammatory and infectious diseases …

Guidelines for the treatment of chronic spontaneous urticaria (CSU) recommend the use of
the IgE-targeted biologic omalizumab in patients with antihistamine-refractory disease. The …

Objective Chronic urticaria (CU) is a common, heterogeneous, and debilitating disease.
Antihistamines and omalizumab are the mainstay therapies of CU. Additional treatment …

Studies with mouse models demonstrate 2 pathways of systemic anaphylaxis: a classic
pathway mediated by IgE, FcɛRI, mast cells, histamine, and platelet-activating factor (PAF) …

The highly destructive mechanisms by which the immune system faces microbial infections
is under the control of a series of inhibitory receptors. While most of these receptors prevent …

The CD300 family of molecules modulates a broad and diverse array of immune cell
processes via their paired activating and inhibitory receptor functions. The description that …