The emerging role of exosomes as novel therapeutics: Biology, technologies, clinical applications, and the next
Y Song, Y Kim, S Ha, S Sheller‐Miller… - American Journal of …, 2021 - Wiley Online Library
The extracellular vesicles (EVs) research area has grown rapidly because of their pivotal
roles in intercellular communications and maintaining homeostasis of individual organism …
roles in intercellular communications and maintaining homeostasis of individual organism …
Exosomal delivery of NF-κB inhibitor delays LPS-induced preterm birth and modulates fetal immune cell profile in mouse models
Accumulation of immune cells and activation of the pro-inflammatory transcription factor NF-
κB in feto-maternal uterine tissues is a key feature of preterm birth (PTB) pathophysiology …
κB in feto-maternal uterine tissues is a key feature of preterm birth (PTB) pathophysiology …
Vaginal Nanoformulations for the Management of Preterm Birth
Preterm birth (PTB) is a leading cause of infant morbidity and mortality in the world. In 2020,
1 in 10 infants were born prematurely in the United States. The World Health Organization …
1 in 10 infants were born prematurely in the United States. The World Health Organization …
Upregulation of TNF-α and IL-6 induces preterm premature rupture of membranes by activation of ADAMTS-9 in embryonic membrane cells
W Li, X Zhao, S Li, X Chen, H Cui, Y Chang, R Zhang - Life Sciences, 2020 - Elsevier
Aim To investigate the role of thrombospondin motifs 9 (ADAMTS9) in preterm premature
rupture of membranes (pPROM). Materials and methods ADAMTS9 levels were measured in …
rupture of membranes (pPROM). Materials and methods ADAMTS9 levels were measured in …
17-α hydroxyprogesterone nanoemulsifying preconcentrate-loaded vaginal tablet: A novel non-invasive approach for the prevention of preterm birth
Preterm birth (PTB) is a major cause of infant mortality in the United States and around the
globe. Makena®—once-a-week intramuscular injection of 17-α Hydroxyprogesterone …
globe. Makena®—once-a-week intramuscular injection of 17-α Hydroxyprogesterone …
Development of a solid supersaturated self-nanoemulsifying preconcentrate (S-superSNEP) of fenofibrate using dimethylacetamide and a novel co-processed …
Background: Recrystallization of drug and incomplete drug release from liquisolid
formulation are two major hurdles in the development of a supersaturated self …
formulation are two major hurdles in the development of a supersaturated self …
Cadmium induces inflammatory cytokines through activating Akt signaling in mouse placenta and human trophoblast cells
J Hu, H Wang, YF Hu, XF Xu, YH Chen, MZ Xia… - Placenta, 2018 - Elsevier
Introduction Several reports demonstrated that cadmium (Cd) had proinflammatory activities.
The present study aimed to investigate whether Cd induces inflammatory cytokines in …
The present study aimed to investigate whether Cd induces inflammatory cytokines in …
A vaginal nanoformulation of a SphK inhibitor attenuates lipopolysaccharide-induced preterm birth in mice
Aim: Previously, we have shown that inhibition of SphK by the SphK inhibitor-II (SKI II)
prevents lipopolysaccharide-induced preterm birth in mice. The aim of this study was to …
prevents lipopolysaccharide-induced preterm birth in mice. The aim of this study was to …
Sodium hydrogen exchanger regulatory factor-1 (NHERF1) regulates fetal membrane inflammation
AK Kammala, S Sheller-Miller, E Radnaa… - International journal of …, 2020 - mdpi.com
The fetal inflammatory response, a key contributor of infection-associated preterm birth
(PTB), is mediated by nuclear factor kappa B (NF-kB) activation. Na+/H+ exchanger …
(PTB), is mediated by nuclear factor kappa B (NF-kB) activation. Na+/H+ exchanger …
The Release of the Bromodomain Ligand N,N-Dimethylacetamide Adds Bioactivity to a Resorbable Guided Bone Regeneration Membrane in a Rabbit Calvarial …
N, N-Dimethylacetamide (DMA) is FDA approved as an excipient and is used as drug-
delivery vehicle. Due to its amphipathic nature and diverse bioactivities, it appears to be a …
delivery vehicle. Due to its amphipathic nature and diverse bioactivities, it appears to be a …