The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …

The study of homologous recombination has its historical roots in meiosis. In this context,
recombination occurs as a programmed event that culminates in the formation of crossovers …

Meiotic recombination involves the formation and repair of programmed DNA double-strand
breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent …

Meiosis, the mechanism of creating haploid gametes, is a complex cellular process
observed across sexually reproducing organisms. Fundamental to meiosis is the process of …

Meiotic recombination between homologous chromosomes initiates via programmed DNA
double-strand breaks (DSBs), generated by complexes comprising Spo11 transesterase …

Meiotic recombination is essential for fertility in most sexually reproducing species. This
process also creates new combinations of alleles and has important consequences for …

Recombination in meiosis is a fascinating case study for the coordination of chromosomal
duplication, repair, and segregation with each other and with progression through a cell …

Homologous recombination is essential during meiosis in most sexually reproducing
organisms. In budding yeast, and most likely in other organisms as well, meiotic …

Eukaryotic DNA replication is regulated to ensure all chromosomes replicate once and only
once per cell cycle. Replication begins at many origins scattered along each chromosome …

Meiotic recombination events are distributed unevenly throughout eukaryotic genomes. This
inhomogeneity leads to distortions of genetic maps that can hinder the ability of geneticists …