The current treatment strategies in advanced malignancies remain limited. Notably,
immunotherapies have raised hope for a successful control of these advanced diseases, but …

Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune
cell types and are generally categorized into either of two functionally contrasting subtypes …

The cellular and molecular mechanisms underlying tumor cell PD-L1 (tPD-L1) function in
tumor immune evasion are incompletely understood. We report here that tPD-L1 does not …

Macrophages are critical mediators of tissue homeostasis, with tumours distorting this
proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest …

Infiltration of macrophages in solid tumours is associated with poor prognosis and correlates
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …

Immunotherapy is revolutionizing the clinical management of multiple tumors. However, only
a fraction of patients with cancer responds to immunotherapy, and currently available …

Cellular associations in the bone microenvironment are involved in modulating the balance
between bone remodeling and resorption, which is necessary for maintaining a normal bone …

Myeloid cells comprise a major component of the tumor microenvironment (TME) that
promotes tumor growth and immune evasion. By employing a small-molecule inhibitor of …

Macrophages are the most important phagocytes in vivo. However, the tumor
microenvironment can affect the function and polarization of macrophages and form tumor …

Established evidence demonstrates that tumor-infiltrating myeloid cells promote rather than
stop-cancer progression. Tumor-associated macrophages (TAMs) are abundantly present at …