High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Self-assembled monolayers of thiolates on metals as a form of nanotechnology

JC Love, LA Estroff, JK Kriebel, RG Nuzzo… - Chemical …, 2005 - ACS Publications
Nanoscience includes the study of objects and systems in which at least one dimension is 1-
100 nm. The objects studied in this range of sizes are larger than atoms and small …

Effect of wettability and surface functional groups on protein adsorption and cell adhesion using well-defined mixed self-assembled monolayers

Y Arima, H Iwata - Biomaterials, 2007 - Elsevier
Self-assembled monolayers (SAMs) of alkanethiols, which can provide flat and chemically
well-defined surfaces, were employed as model surfaces to understand cellular interaction …

Adaptation of high-throughput screening in drug discovery—toxicological screening tests

P Szymański, M Markowicz… - International journal of …, 2011 - mdpi.com
High-throughput screening (HTS) is one of the newest techniques used in drug design and
may be applied in biological and chemical sciences. This method, due to utilization of …

The sweet and sour of cancer: glycans as novel therapeutic targets

MM Fuster, JD Esko - Nature Reviews Cancer, 2005 - nature.com
A growing body of evidence supports crucial roles for glycans at various pathophysiological
steps of tumour progression. Glycans regulate tumour proliferation, invasion …

Patterned superhydrophobic surfaces: toward a synthetic mimic of the Namib Desert beetle

L Zhai, MC Berg, FÇ Cebeci, Y Kim, JM Milwid… - Nano Letters, 2006 - ACS Publications
The present study demonstrates a surface structure that mimics the water harvesting wing
surface of the Namib Desert beetle. Hydrophilic patterns on superhydrophobic surfaces …

A defined glycosaminoglycan-binding substratum for human pluripotent stem cells

JR Klim, L Li, PJ Wrighton, MS Piekarczyk… - Nature …, 2010 - nature.com
To exploit the full potential of human pluripotent stem cells for regenerative medicine,
developmental biology and drug discovery, defined culture conditions are needed. Media of …

Materials control of the epigenetics underlying cell plasticity

S Nemec, KA Kilian - Nature Reviews Materials, 2021 - nature.com
The dynamic epigenetic landscape directs gene expression patterns that dictate cellular
form and function, and drive the assembly of cells into tissues. The high degree of plasticity …

High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research

TG Fernandes, MM Diogo, DS Clark, JS Dordick… - Trends in …, 2009 - cell.com
Cellular microarrays are powerful experimental tools for high-throughput screening of large
numbers of test samples. Miniaturization increases assay throughput while reducing reagent …

Diversity of phage-displayed libraries of peptides during panning and amplification

R Derda, SKY Tang, SC Li, S Ng, W Matochko… - Molecules, 2011 - mdpi.com
The amplification of phage-displayed libraries is an essential step in the selection of ligands
from these libraries. The amplification of libraries, however, decreases their diversity and …