Over the last six decades, lithium has been considered the gold standard treatment for the
long-term management of bipolar disorder due to its efficacy in preventing both manic and …

Introduction Induced pluripotent stem cells (iPSCs) are cells derived from somatic cells via
reprogramming techniques. The iPSC approach has been increasingly used in …

The Shank3 gene encodes the major postsynaptic scaffolding protein SHANK3. Its mutation
causes a syndromic form of autism spectrum disorder (ASD): Phelan-McDermid Syndrome …

Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of
action is incompletely understood, and prediction of treatment outcomes is limited. In our …

Background: The mechanism of lithium treatment responsiveness in bipolar disorder (BD)
remains unclear. The aim of this study was to explore the utility of correlation coefficients and …

Bipolar disorder (BP) is a recurring psychiatric condition characterized by alternating
episodes of low energy (depressions) followed by manias (high energy). Cortical network …

Lung cancer poses a global health challenge, necessitating advanced diagnostics for
improved outcomes. Intensive efforts are ongoing to pinpoint early detection biomarkers …

Bipolar disorder (BD) is a severe chronic disorder that represents one of the main causes of
disability among young people. To date, no reliable biomarkers are available to inform the …

Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of
action is incompletely understood, and prediction of treatment outcomes is limited. In our …

The gene A-kinase anchoring protein 11 (AKAP11) recently emerged as a shared risk factor
between bipolar disorder and schizophrenia, driven by large-effect loss-of-function (LoF) …