New advances in the pharmacology and toxicology of lithium: a neurobiologically oriented overview

A Bortolozzi, G Fico, M Berk, M Solmi, M Fornaro… - Pharmacological …, 2024 - ASPET
Over the last six decades, lithium has been considered the gold standard treatment for the
long-term management of bipolar disorder due to its efficacy in preventing both manic and …

[HTML][HTML] On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol

W Niemis, SR Peterson, C Javier, A Nguyen, S Subiah… - Plos one, 2023 - journals.plos.org
Introduction Induced pluripotent stem cells (iPSCs) are cells derived from somatic cells via
reprogramming techniques. The iPSC approach has been increasingly used in …

[HTML][HTML] Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by lithium

V Ioannidis, R Pandey, HF Bauer, M Schön… - Molecular …, 2024 - nature.com
The Shank3 gene encodes the major postsynaptic scaffolding protein SHANK3. Its mutation
causes a syndromic form of autism spectrum disorder (ASD): Phelan-McDermid Syndrome …

[HTML][HTML] Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study

AH Ou, SB Rosenthal, M Adli, K Akiyama… - Translational …, 2024 - nature.com
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of
action is incompletely understood, and prediction of treatment outcomes is limited. In our …

[HTML][HTML] Possible Role of Correlation Coefficients and Network Analysis of Multiple Intracellular Proteins in Blood Cells of Patients with Bipolar Disorder in Studying the …

K Gao, M Ayati, NM Kaye, M Koyuturk… - Journal of clinical …, 2024 - mdpi.com
Background: The mechanism of lithium treatment responsiveness in bipolar disorder (BD)
remains unclear. The aim of this study was to explore the utility of correlation coefficients and …

[HTML][HTML] Human-Induced Pluripotent Stem Cell (iPSC)-Derived GABAergic Neuron Differentiation in Bipolar Disorder

DJ Schill, D Attili, CJ DeLong, MG McInnis… - Cells, 2024 - mdpi.com
Bipolar disorder (BP) is a recurring psychiatric condition characterized by alternating
episodes of low energy (depressions) followed by manias (high energy). Cortical network …

Long-read sequencing unveils novel somatic variants and methylation patterns in the genetic information system of early lung cancer

X Cui, Q Lin, M Chen, Y Wang, Y Wang, Y Wang… - Computers in Biology …, 2024 - Elsevier
Lung cancer poses a global health challenge, necessitating advanced diagnostics for
improved outcomes. Intensive efforts are ongoing to pinpoint early detection biomarkers …

[HTML][HTML] RNA biomarkers in bipolar disorder and response to mood stabilizers

C Pisanu, A Squassina - International Journal of Molecular Sciences, 2023 - mdpi.com
Bipolar disorder (BD) is a severe chronic disorder that represents one of the main causes of
disability among young people. To date, no reliable biomarkers are available to inform the …

[HTML][HTML] Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study

J Kelsoe, A Ou, S Rosenthal, M Adli, K Akiyama… - Research …, 2023 - ncbi.nlm.nih.gov
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of
action is incompletely understood, and prediction of treatment outcomes is limited. In our …

Transcriptomic and epigenomic consequences of heterozygous loss of function mutations in AKAP11, the first large-effect shared risk gene for bipolar disorder and …

N Farhangdoost, C Liao, Y Liu, M Alda, PA Dion… - bioRxiv, 2024 - biorxiv.org
The gene A-kinase anchoring protein 11 (AKAP11) recently emerged as a shared risk factor
between bipolar disorder and schizophrenia, driven by large-effect loss-of-function (LoF) …