Synthesis and biological evaluation of some 1‐naphthol derivatives as antioxidants, acetylcholinesterase, and carbonic anhydrase inhibitors

M Erdoğan, L Polat Köse, S Eşsiz… - Archiv der …, 2021 - Wiley Online Library
A series of some naphthol derivatives 4a–f, 5a, f, 6a, and 7a, b (six novel ones: 4c, d, 5a, 6a,
7a, b) bearing F, Cl, Br, OMe, and dioxole substituents at different positions of the aromatic …

New 4-methanesulfonyloxy benzohydrazide derivatives as potential antioxidant and carbonic anhydrase I and II inhibitors: synthesis, characterization, molecular …

A Köse, LP Köse, H Şenol… - Journal of Molecular …, 2025 - Elsevier
As an archetypal molecule, hydrazides have a crucial vital role in numerous applications, so
hydrazide-related inhibitors, especially sulfur-enriched, are favored. In the present work, we …

Evaluation of cytotoxic potentials of some isoindole-1, 3-dione derivatives on HeLa, C6 and A549 cancer cell lines

A Tan, AS Yaglioglu, NH Kishali, E Sahin… - Medicinal …, 2020 - ingentaconnect.com
Background: Norcantharimides are known as norcantharidine derivatives and contain an
isoindole skeleton structure. Isoindole derivatives have positive effect on inflammatory …

Novel hybrid isoindole‐1,3(2H)‐dione compounds containing a 1H‐tetrazole moiety: Synthesis, biological evaluation, and molecular docking studies

A Tan, S Kizilkaya, SAA Noma, B Ates… - Journal of biochemical …, 2022 - Wiley Online Library
In this study, novel hybrid isoindole‐1, 3 (2H)‐dione compounds (10 and 11) carrying a 1H‐
tetrazole moiety were synthesized, characterized and their inhibitory properties against …

Dual delivery of platelet‐derived growth factor and bone morphogenetic factor‐6 on titanium surface to enhance the early period of implant osseointegration

HG Keceli, C Bayram, E Celik, N Ercan… - Journal of …, 2020 - Wiley Online Library
Objective To test the surface properties and in vitro effects of a new sequential release
system on MC3T3‐E1 cells for improved osseointegration. Background BMP6‐loaded …

Synthesis, cytotoxicity, and antibacterial studies of 2,4,5,6‐substituted hexahydro‐1H‐isoindole‐1,3(2H)‐dione

E Yetişkin, Ö Gündoğdu, D Mete… - Chemical Biology & …, 2023 - Wiley Online Library
In this study, synthesis of novel isoindole‐1, 3‐dione analogues bearig halo, hydroxy, and
acetoxy groups at the position 4, 5, 6 of the bicyclic imide ring was performed to examine …

Evaluation of isoindole derivatives: Antioxidant potential and cytotoxicity in the HT‐29 colon cancer cells

A Kılıç Süloğlu, G Selmanoglu… - Archiv der …, 2020 - Wiley Online Library
Norcantharimides have an isoindole skeleton structure, and some isoindoline derivatives
have positive effects on inflammatory pathologies, including cancers. The present study …

Remarkable reactivity of boron-substituted furans in the Diels–Alder reactions with maleic anhydride

NS Medrán, F Dezotti, SC Pellegrinet - Organic letters, 2019 - ACS Publications
The reactivity of boron-substituted furans as dienes in the Diels–Alder reaction with maleic
anhydride has been investigated. Gratifyingly, the furans with boryl substituents at C-3 gave …

Regio-and stereo-chemical ring-opening reactions of the 2, 3-epoxy alcohol derivative with nucleophiles: Explanation of the structures and C-2 selectivity supported …

Ö Gündoğdu, A Atalay, N Çelebioğlu, B Anıl… - Journal of Molecular …, 2022 - Elsevier
The ring-opening reactions of (1aS, 2S, 6bR)-5-ethyl-2-hydroxyhexahydro-4H-oxireno [2, 3-
e] isoindole-4, 6 (5H)-dione were investigated under very mild and nonchelated conditions …

Synthesis and biological evaluation of new chloro/acetoxy substituted isoindole analogues as new tyrosine kinase inhibitors

A Köse, M Kaya, NH Kishalı, A Akdemir, E Şahin… - Bioorganic …, 2020 - Elsevier
We have developed a versatile synthetic approach for the synthesis of new isoindole
derivatives via the cleavage of ethers from tricyclic imide skeleton compounds. An exo …