Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Nitrate reductase (NR) is a key enzyme for nitrogen acquisition by plants, algae, yeasts, and
fungi. Nitrate, its main substrate, is required for signaling and is widely distributed in diverse …

Over the past decades, peroxisomes have emerged as key regulators in overall cellular lipid
and reactive oxygen species metabolism. In mammals, these organelles have also been …

In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we
identify a common missense variant in the Mitochondrial Amidoxime Reducing Component …

The heme iron complex is one of the most important cofactors in biological systems (Figure
1). The major functions of the heme iron complex are to serve as the O2 binding site for …

Reduction-oxidation or “redox” reactions are an integral part of a broad range of cellular
processes such as gene expression, energy metabolism, protein import and folding, and …

Inorganic nitrate (NO3−), nitrite (NO2−) and NO are nitrogenous species with a diverse and
interconnected chemical biology. The formation of NO from nitrate and nitrite via a reductive …

Elevated levels of reactive nitrogen species, alteration in redox balance and deregulated
redox signaling are common hallmarks of cancer progression and chemoresistance …

Background & Aims Non-alcoholic fatty liver disease (NAFLD) has a prevalence of∼ 25%
worldwide, with significant public health consequences yet few effective treatments. Human …