Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known
as the M-current. Due to its particular characteristics, Kv7 channels show pronounced …

In the human genome more than 400 genes encode ion channels, which are
transmembrane proteins mediating ion fluxes across membranes. Being expressed in all …

The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is
an important drug target to treat epilepsy, pain and several other diseases related to …

Objective: To advance the understanding of KCNQ2 encephalopathy genotype–phenotype
relationships and to begin to assess the potential of selective KCNQ channel openers as …

Seizures are the most common neurological manifestation in the newborn period, with an
estimated incidence of 1.8–3.5 per 1000 live births. Prolonged or intractable seizures have a …

Mutations in the KV7. 2 gene encoding for voltage-dependent K+ channel subunits cause
neonatal epilepsies with wide phenotypic heterogeneity. Two mutations affecting the same …

Mitochondria provide energy to the cell during aerobic respiration by supplying~ 95% of the
adenosine triphosphate (ATP) molecules via oxidative phosphorylation. These organelles …

Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …

Background Prior studies have revealed remarkable phenotypic heterogeneity in KCNQ2-
related disorders, correlated with effects on biophysical features of heterologously …

Hydrogen sulfide (H 2 S) is a crucial signaling molecule involved in several physiological
and pathological processes. Nonetheless, the role of this gasotransmitter in the …