Although cardiac abnormalities have been observed in a growing class of human disorders
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …

Initially identified in Drosophila, the Hippo signaling pathway has emerged as an
evolutionarily conserved tumor suppressor pathway that controls tissue growth and organ …

During vertebrate development, cells must proliferate, move, and differentiate to form
complex shapes. Elucidating the mechanisms underlying the molecular and cellular …

The Hippo pathway, an evolutionarily conserved signalling mechanism, controls organ size
and tumourigenesis. Increasing lines of evidence suggest that autophagy, an important …

Vision impairment places a serious burden on the aging society, affecting the lives of
millions of people. Many retinal diseases are of genetic origin, of which over 50% are due to …

Tissues undergo distinct morphogenetic processes to achieve similarly shaped structures. In
the heart, cardiomyocytes in both the ventricle and atrium build internal structures for …

Advanced pancreatic ductal adenocarcinomas (PDACs) respond poorly to all therapies,
including the first-line treatment, chemotherapy, the latest immunotherapies, and KRAS …

Cilia are small organelles present at the surface of most differentiated cells where they act
as sensors for mechanical or biochemical stimuli. Cilia assembly and function require the …

Cardiac regenerative capacity varies widely among vertebrates. Zebrafish can robustly
regenerate injured hearts and are excellent models to study the mechanisms of heart …

Initially discovered as the smallest component of the intraflagellar transport (IFT) system, the
IFT20 protein has been found to be implicated in several unconventional mechanisms …