Single-molecule FRET spectroscopy and the polymer physics of unfolded and intrinsically disordered proteins
The properties of unfolded proteins have long been of interest because of their importance
to the protein folding process. Recently, the surprising prevalence of unstructured regions or …
to the protein folding process. Recently, the surprising prevalence of unstructured regions or …
Single-molecule spectroscopy of protein folding dynamics—expanding scope and timescales
Single-molecule spectroscopy has developed into an important method for probing protein
structure and dynamics, especially in structurally heterogeneous systems. A broad range of …
structure and dynamics, especially in structurally heterogeneous systems. A broad range of …
Quantifying internal friction in unfolded and intrinsically disordered proteins with single-molecule spectroscopy
Internal friction, which reflects the “roughness” of the energy landscape, plays an important
role for proteins by modulating the dynamics of their folding and other conformational …
role for proteins by modulating the dynamics of their folding and other conformational …
Comprehensive structural and dynamical view of an unfolded protein from the combination of single-molecule FRET, NMR, and SAXS
M Aznauryan, L Delgado, A Soranno… - Proceedings of the …, 2016 - National Acad Sciences
The properties of unfolded proteins are essential both for the mechanisms of protein folding
and for the function of the large group of intrinsically disordered proteins. However, the …
and for the function of the large group of intrinsically disordered proteins. However, the …
Single-molecule studies of intrinsically disordered proteins
The last 15 years saw a dramatic increase in the number of published papers exposing
research related to the concept of protein disorder and a concomitant increase in the …
research related to the concept of protein disorder and a concomitant increase in the …
Solvent viscosity and friction in protein folding dynamics
SJ Hagen - Current Protein and Peptide Science, 2010 - ingentaconnect.com
The famous Kramers rate theory for diffusion-controlled reactions has been extended in
numerous ways and successfully applied to many types of reactions. Its application to …
numerous ways and successfully applied to many types of reactions. Its application to …
Integrated view of internal friction in unfolded proteins from single-molecule FRET, contact quenching, theory, and simulations
The dynamics of proteins, which are essential for both folding and function, are known to be
strongly dependent on solvent viscosity or friction. However, an increasing number of …
strongly dependent on solvent viscosity or friction. However, an increasing number of …
Molecular origins of internal friction effects on protein-folding rates
D De Sancho, A Sirur, RB Best - Nature communications, 2014 - nature.com
Recent experiments on protein-folding dynamics have revealed strong evidence for internal
friction effects. That is, observed relaxation times are not simply proportional to the solvent …
friction effects. That is, observed relaxation times are not simply proportional to the solvent …
Butane dihedral angle dynamics in water is dominated by internal friction
JO Daldrop, J Kappler, FN Brünig… - Proceedings of the …, 2018 - National Acad Sciences
The dihedral dynamics of butane in water is known to be rather insensitive to the water
viscosity; possible explanations for this involve inertial effects or Kramers' turnover, the finite …
viscosity; possible explanations for this involve inertial effects or Kramers' turnover, the finite …
Localizing internal friction along the reaction coordinate of protein folding by combining ensemble and single-molecule fluorescence spectroscopy
Abstract Theory, simulations and experimental results have suggested an important role of
internal friction in the kinetics of protein folding. Recent experiments on spectrin domains …
internal friction in the kinetics of protein folding. Recent experiments on spectrin domains …