Among cell cycle regulatory proteins that are activated following DNA damage, the cyclin-
dependent kinase inhibitor p21CDKN1A plays essential roles in the DNA damage response …

Highlights•Discusses biological advantages of co-delivery of multiple agents in cancer
therapy.•Nanovehicles can be used for simultaneous delivery of drug–drug or drug–gene …

MicroRNAs (miRNA) have rapidly emerged as modulators of gene expression in cancer in
which they may have great diagnostic and therapeutic import. MicroRNA-199a-3p (miR …

There is increasing evidence that some cancers are hierarchically organized, sustained by a
relatively rare population of cancer-initiating cells (C-ICs). Although the capacity to initiate …

The tumor microenvironment plays an important role in the tumor's progression and
metastasis. Therefore, successful alteration of this delicate setting against the tumor's favor …

The relevance of potentially reversible post-translational modifications required for
controlling cellular processes in cancer is one of the most thriving arenas of cellular and …

Cisplatin-based chemotherapy has been used for more than four decades as a standard
therapeutic option in several tumor entities. However, being a multifaceted and …

The response of advanced hepatocellular carcinoma (HCC) to pharmacological treatments
is unsatisfactory and heterogeneous. Inactivation of tumor suppressor genes (TSGs) by …

The impaired ubiquitin-proteasome activity is believed to be one of the leading factors that
contribute to Parkinson disease pathogenesis partially by causing α-synuclein aggregation …

The cyclin-dependent kinase inhibitor p21 (p21WAF1/Cip1) is a multifunctional protein
known to promote cell cycle arrest and survival in response to p53-dependent and p53 …