The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …

The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

Interactions between proteins are orchestrated in a precise and time-dependent manner,
underlying cellular function. The binding affinity, defined as the strength of these …

The tumor suppressor protein p53 induces or represses the expression of a variety of target
genes involved in cell cycle control, senescence, and apoptosis in response to oncogenic or …

Identifying relationships between function, amino acid sequence, and protein structure
represents a major challenge. In this study, we propose a bioinformatics approach that …

The tumor suppressor protein p53 is inactivated by mutation in about half of all human
cancers. Most mutations are located in the DNA-binding domain of the protein. It is …

The tumor-suppressor protein p53 is among the most effective of the cell's natural defenses
against cancer. In response to cellular stress, p53 binds as a tetramer to diverse DNA targets …

Proteins with intrinsically disordered domains are implicated in a vast range of biological
processes, especially in cell signaling and regulation. Having solved the quaternary …

A common ancestor to the three p53 family members of human genes p53, p63, and p73 is
first detected in the evolution of modern‐day sea anemones, in which both structurally and …