Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

The basic premise of the epitope-based approach to vaccine development is that, in certain
cases, the responses induced by the natural immunogen are not optimal, and can be …

Long-term immunological memory to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is crucial for the development of population-level immunity, which is the aim …

Background T cells recognize a complex between a specific major histocompatibility
complex (MHC) molecule and a particular pathogen-derived epitope. A given epitope will …

Abstract During 1989–1999, 11 volunteers were immunized by the bites of 1001–2927
irradiated mosquitoes harboring infectious sporozoites of Plasmodium falciparum (Pf) strain …

Background In an epitope-based vaccine setting, the use of conserved epitopes would be
expected to provide broader protection across multiple strains, or even species, than …

Abstract Four HLA-DR-restricted HIV-derived Th lymphocyte (HTL) epitopes cross-reactive
with the murine IA b class II molecule were used to evaluate different vaccine design …

Vigorous virus-specific CD4+ T-helper-cell responses are associated with successful control
of hepatitis C virus (HCV) and other human viral infections, but the breadth and specificity of …

Introduction Due to overcome the hardness of the vaccine design, computational
vaccinology is emerging widely. Prediction of T cell and B cell epitopes, antigen processing …

Annually, malaria causes> 300 million clinical cases and 1 million deaths, is responsible for
the loss of> 1% of gross domestic product (GDP) in Africa and is a serious concern for …