Adipose tissue is a dynamic endocrine organ that secretes a number of factors that are
increasingly recognized to contribute to systemic and vascular inflammation. Several of …

Diabetes mellitus (DM) is characterized by fasting hyperglycaemia and a high risk of
atherothrombotic disorders affecting the coronary, cerebral and peripheral arterial trees. The …

ContextPlasma fibrinogen levels may be associated with the risk of coronary heart disease
(CHD) and stroke. ObjectiveTo assess the relationships of fibrinogen levels with risk of major …

Cardiovascular disease (CVD) is the leading cause of mortality in women. In fact, CVD is
responsible for a third of all deaths of women worldwide and half of all deaths of women …

Atherothrombotic complications are the main cause of mortality in subjects with diabetes.
Premature atherosclerosis, increased platelet reactivity and activation of coagulation factors …

Obese patients are at risk for the development of cardiovascular diseases, which can in part
be explained by disturbances in the haemostatic and fibrinolytic systems. Indeed, obese …

In adipose tissue from both obese mice and humans, plasminogen activator inhibitor 1 (PAI-
1) expression has been reported to be upregulated to levels of increased plasma PAI-1. This …

White adipose tissue is a mesenchymal tissue that begins developing in the fetus.
Classically known for storing the body's fuel reserves, adipose tissue is now recognized as …

Atherosclerosis and its thrombotic complications are the major cause of morbidity and
mortality in the industrialized world. The progression of atherosclerotic plaques in the …

The notion that fibrinogen is strongly, consistently, and independently related to
cardiovascular risk has been widely accepted. The evidence is based on numerous …