[HTML][HTML] The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases

MR Zinatizadeh, B Schock, GM Chalbatani, PK Zarandi… - Genes & diseases, 2021 - Elsevier
The nuclear factor kappa B (NF-êB) family of transcription factors plays an essential role as
stressors in the cellular environment, and controls the expression of important regulatory …

Signaling via the NFκB system

S Mitchell, J Vargas, A Hoffmann - … Reviews: Systems Biology …, 2016 - Wiley Online Library
The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …

NFKB1: a suppressor of inflammation, ageing and cancer

T Cartwright, ND Perkins, C L. Wilson - The FEBS journal, 2016 - Wiley Online Library
The pleiotropic consequences of nuclear factor of kappa light polypeptide gene enhancer in
B‐cells (NF‐κB) pathway activation result from the combinatorial effects of the five subunits …

Genome reading by the NF-κB transcription factors

MC Mulero, VYF Wang, T Huxford… - Nucleic acids …, 2019 - academic.oup.com
The NF-κB family of dimeric transcription factors regulates transcription by selectively
binding to DNA response elements present within promoters or enhancers of target genes …

The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts

S Mitchell, R Tsui, ZC Tan, A Pack, A Hoffmann - Science signaling, 2023 - science.org
The nuclear factor κB (NF-κB) system is critical for various biological functions in numerous
cell types, including the inflammatory response, cell proliferation, survival, differentiation …

An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-κB module

M Chawla, T Mukherjee, A Deka… - Proceedings of the …, 2021 - National Acad Sciences
Aberrant inflammation, such as that associated with inflammatory bowel disease (IBD), is
fueled by the inordinate activity of RelA/NF-κB factors. As such, the canonical NF-κB module …

Inflammation and NF-κB signaling in prostate cancer: Mechanisms and clinical implications

J Staal, R Beyaert - Cells, 2018 - mdpi.com
Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and
benign. Due to its high prevalence, it is, however, still the second most common cause of …

New insights into NF-κB signaling in innate immunity: focus on immunometabolic crosstalks

D Iacobazzi, P Convertini, S Todisco, A Santarsiero… - Biology, 2023 - mdpi.com
Simple Summary NF-κB transcription factors are leading modulators of innate immunity.
Recent investigations reveal their interplay with energetic metabolism as a central task of …

The NF-κB transcriptional network is a high-dose vitamin C-targetable vulnerability in breast cancer

A Mussa, HA Afolabi, NH Syed, M Talib, AH Murtadha… - Biomedicines, 2023 - mdpi.com
Breast cancer (BC) is the most common cancer type among women with a distinct clinical
presentation, but the survival rate remains moderate despite advances in multimodal …

Flow-Induced Shear Stress Primes NLRP3 Inflammasome Activation in Macrophages via Piezo1

A Fish, A Kulkarni - ACS Applied Materials & Interfaces, 2024 - ACS Publications
The NLRP3 inflammasome is a crucial component of the innate immune system, playing a
pivotal role in initiating and regulating the body's inflammatory response to various …