Hierarchically oriented organization in supramolecular peptide crystals

C Yuan, W Ji, R Xing, J Li, E Gazit, X Yan - Nature Reviews Chemistry, 2019 - nature.com
Hierarchical self-assembly and crystallization with long-range ordered spatial arrangement
is ubiquitous in nature and plays an essential role in the regulation of structures and …

Modeling semiflexible polymer networks

CP Broedersz, FC MacKintosh - Reviews of Modern Physics, 2014 - APS
This is an overview of theoretical approaches to semiflexible polymers and their networks.
Such semiflexible polymers have large bending rigidities that can compete with the entropic …

Actin bundles dynamics and architecture

S Rajan, DS Kudryashov, E Reisler - Biomolecules, 2023 - mdpi.com
Cells use the actin cytoskeleton for many of their functions, including their division,
adhesion, mechanosensing, endo-and phagocytosis, migration, and invasion. Actin bundles …

Structure and dynamics of cross-linked actin networks

O Lieleg, MMAE Claessens, AR Bausch - Soft Matter, 2010 - pubs.rsc.org
The actin cytoskeleton, a network of protein-polymers, is responsible for the mechanical
stability of cells. This biopolymer network is also crucial for processes that require spatial …

Synaptopodin regulates the actin-bundling activity of α-actinin in an isoform-specific manner

K Asanuma, K Kim, J Oh, L Giardino… - The Journal of …, 2005 - Am Soc Clin Investig
Synaptopodin is the founding member of a novel class of proline-rich actin-associated
proteins highly expressed in telencephalic dendrites and renal podocytes. Synaptopodin …

Extracellular barriers in respiratory gene therapy

N Sanders, C Rudolph, K Braeckmans… - Advanced drug delivery …, 2009 - Elsevier
Respiratory gene therapy has been considered for the treatment of a broad range of
pulmonary disorders. However, respiratory secretions form an important barrier towards the …

Fascin-and α-actinin-bundled networks contain intrinsic structural features that drive protein sorting

JD Winkelman, C Suarez, GM Hocky, AJ Harker… - Current Biology, 2016 - cell.com
Cells assemble and maintain functionally distinct actin cytoskeleton networks with various
actin filament organizations and dynamics through the coordinated action of different sets of …

Spontaneous and x-ray–triggered crystallization at long range in self-assembling filament networks

H Cui, ET Pashuck, YS Velichko, SJ Weigand… - Science, 2010 - science.org
We report here crystallization at long range in networks of like-charge supramolecular
peptide filaments mediated by repulsive forces. The crystallization is spontaneous beyond a …

Disease-associated mutant α-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity

A Weins, JS Schlondorff, F Nakamura… - Proceedings of the …, 2007 - National Acad Sciences
α-Actinin-4 is a widely expressed protein that employs an actin-binding site with two
calponin homology domains to crosslink actin filaments (F-actin) in a Ca2+-sensitive manner …

Actin cross-link assembly and disassembly mechanics for α-actinin and fascin

DS Courson, RS Rock - Journal of Biological Chemistry, 2010 - ASBMB
Self-assembly of complex structures is commonplace in biology but often poorly understood.
In the case of the actin cytoskeleton, a great deal is known about the components that …