[HTML][HTML] Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases
The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …
CC chemokine receptors and chronic inflammation—therapeutic opportunities and pharmacological challenges
Chemokines are a family of low molecular weight proteins with an essential role in leukocyte
trafficking during both homeostasis and inflammation. The CC class of chemokines consists …
trafficking during both homeostasis and inflammation. The CC class of chemokines consists …
A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection
M Brandes, F Klauschen, S Kuchen, RN Germain - Cell, 2013 - cell.com
For acutely lethal influenza infections, the relative pathogenic contributions of direct viral
damage to lung epithelium versus dysregulated immunity remain unresolved. Here, we take …
damage to lung epithelium versus dysregulated immunity remain unresolved. Here, we take …
Nonclassical Ly6C− monocytes drive the development of inflammatory arthritis in mice
Different subsets and/or polarized phenotypes of monocytes and macrophages may play
distinct roles during the development and resolution of inflammation. Here, we demonstrate …
distinct roles during the development and resolution of inflammation. Here, we demonstrate …
Yoga maintains Th17/Treg cell homeostasis and reduces the rate of T cell aging in rheumatoid arthritis: a randomized controlled trial
The pathogenesis of rheumatoid arthritis (RA) is characterized by a Th17/Treg cell
imbalance. A pro-inflammatory cytokine milieu that promotes the continued proliferation of …
imbalance. A pro-inflammatory cytokine milieu that promotes the continued proliferation of …
[HTML][HTML] Cre-mediated cell ablation contests mast cell contribution in models of antibody-and T cell-mediated autoimmunity
TB Feyerabend, A Weiser, A Tietz, M Stassen, N Harris… - Immunity, 2011 - cell.com
Immunological functions of mast cells remain poorly understood. Studies in Kit mutant mice
suggest key roles for mast cells in certain antibody-and T cell-mediated autoimmune …
suggest key roles for mast cells in certain antibody-and T cell-mediated autoimmune …
The role of neutrophils in autoimmune diseases
Though chronic autoimmune disorders such as rheumatoid arthritis or systemic lupus
erythematosus affect a significant percentage of the human population and strongly diminish …
erythematosus affect a significant percentage of the human population and strongly diminish …
Toll‐like receptor‐mediated IRE1α activation as a therapeutic target for inflammatory arthritis
In rheumatoid arthritis (RA), macrophage is one of the major sources of inflammatory
mediators. Macrophages produce inflammatory cytokines through toll‐like receptor (TLR) …
mediators. Macrophages produce inflammatory cytokines through toll‐like receptor (TLR) …
Epigallocatechin-3-gallate inhibits osteoclastic differentiation by modulating mitophagy and mitochondrial functions
J Sarkar, M Das, MSI Howlader, P Prateeksha… - Cell death & …, 2022 - nature.com
A natural plant product, epigallocatechin-3-gallate (EGCG), was evaluated for its
effectiveness in the regulation of osteoclastogenesis. We found that EGCG inhibited the …
effectiveness in the regulation of osteoclastogenesis. We found that EGCG inhibited the …
K/BxN serum-transfer arthritis as a model for human inflammatory arthritis
AD Christensen, C Haase, AD Cook… - Frontiers in …, 2016 - frontiersin.org
The K/BxN serum-transfer arthritis (STA) model is a murine model in which the
immunological mechanisms occurring in rheumatoid arthritis (RA) and other arthritides can …
immunological mechanisms occurring in rheumatoid arthritis (RA) and other arthritides can …