Stem cell transplantation holds great promise as a potential treatment for currently incurable
retinal degenerative diseases that cause poor vision and blindness. Recently, safety data …

In the developing vertebrate retina, diverse neuronal subtypes originate from multipotent
progenitors in a conserved order and are integrated into an intricate laminated architecture …

Many forms of blindness result from the dysfunction or loss of retinal photoreceptors.
Induced pluripotent stem cells (iPSCs) hold great potential for the modelling of these …

Retinitis pigmentosa (RP) is an irreversible, inherited retinopathy in which early-onset
nyctalopia is observed. Despite the genetic heterogeneity of RP, RPGR mutations are the …

Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent
stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited …

The retinal degenerative diseases, which together constitute a leading cause of hereditary
blindness worldwide, are largely untreatable. Development of reliable methods to culture …

PURPOSE: To describe the histologic development of the human central retina from fetal
week (Fwk) 22 to 13 years. DESIGN: Retrospective observational case series. METHODS …

Humans rely on visual cues to navigate the world around them. Vision begins with the
detection of light by photoreceptor cells in the retina, a light-sensitive tissue located at the …

Retinal degeneration (RD) is one of the dominant causes of irreversible vision impairment
and blindness worldwide. However, the current effective therapeutics for RD in the …

The derivation of three-dimensional (3D) stratified neural retina from pluripotent stem cells
has permitted investigations of human photoreceptors. We have generated a H9 human …