Signaling receptome: a genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction
I Ben-Shlomo, S Yu Hsu, R Rauch, HW Kowalski… - Science's …, 2003 - science.org
Intercellular communication in multicellular organisms requires the relay of extracellular
signals by cell surface proteins to the interiors of cells. The availability of genome sequences …
signals by cell surface proteins to the interiors of cells. The availability of genome sequences …
Cellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction
LM Cotton, MK O'Bryan, BT Hinton - Endocrine reviews, 2008 - academic.oup.com
The major function of the reproductive system is to ensure the survival of the species by
passing on hereditary traits from one generation to the next. This is accomplished through …
passing on hereditary traits from one generation to the next. This is accomplished through …
Development and large scale benchmark testing of the PROSPECTOR_3 threading algorithm
This article describes the PROSPECTOR_3 threading algorithm, which combines various
scoring functions designed to match structurally related target/template pairs. Each variant …
scoring functions designed to match structurally related target/template pairs. Each variant …
The Crystal Structure of Fibroblast Growth Factor (FGF) 19 Reveals Novel Features of the FGF Family and Offers a Structural Basis for Its Unusual Receptor Affinity,
The 22 members of the FGF family have been implicated in cell proliferation, differentiation,
survival, and migration. They are required for both development and maintenance of …
survival, and migration. They are required for both development and maintenance of …
Signaling, internalization, and intracellular activity of fibroblast growth factor
A Więdłocha, V Sørensen - Signalling from Internalized Growth Factor …, 2004 - Springer
Abstract The fibroblast growth factor (FGF) family contains 23 members in mammals
including its prototype members FGF-1 and FGF-2. FGFs have been implicated in regulation …
including its prototype members FGF-1 and FGF-2. FGFs have been implicated in regulation …
FGF-1: from biology through engineering to potential medical applications
M Zakrzewska, E Marcinkowska… - Critical reviews in …, 2008 - Taylor & Francis
Human fibroblast growth factor 1 (FGF-1) is one of the best characterized members of the
FGF superfamily. FGF-1 is a powerful mitogen exhibiting strong action on numerous different …
FGF superfamily. FGF-1 is a powerful mitogen exhibiting strong action on numerous different …
Signalling by the FGFR-like tyrosine kinase, Kringelchen, is essential for bud detachment in Hydra vulgaris
S Sudhop, F Coulier, A Bieller, A Vogt, T Hotz… - 2004 - journals.biologists.com
Signalling through fibroblast growth factors (FGFR) is essential for proper morphogenesis in
higher evolved triploblastic organisms. By screening for genes induced during …
higher evolved triploblastic organisms. By screening for genes induced during …
Conserved intron positions in FGFR genes reflect the modular structure of FGFR and reveal stepwise addition of domains to an already complex ancestral FGFR
N Rebscher, C Deichmann, S Sudhop… - Development genes and …, 2009 - Springer
We have analyzed the evolution of fibroblast growth factor receptor (FGFR) tyrosine kinase
genes throughout a wide range of animal phyla. No evidence for an FGFR gene was found …
genes throughout a wide range of animal phyla. No evidence for an FGFR gene was found …
[HTML][HTML] The localisation of the heparin binding sites of human and murine interleukin-12 within the carboxyterminal domain of the P40 subunit
P Garnier, R Mummery, MJ Forster, B Mulloy, RV Gibbs… - Cytokine, 2018 - Elsevier
We have previously shown that the heterodimeric cytokine interleukin-12, and the
homodimer of its larger subunit p40, both bind to heparin and heparan sulfate with relatively …
homodimer of its larger subunit p40, both bind to heparin and heparan sulfate with relatively …
The Hydra FGFR, Kringelchen, partially replaces the Drosophila Heartless FGFR
A Rudolf, C Hübinger, K Hüsken, A Vogt… - Development genes and …, 2013 - Springer
Fibroblast growth factor receptors (FGFR) are highly conserved receptor tyrosine kinases,
and evolved early in metazoan evolution. In order to investigate their functional …
and evolved early in metazoan evolution. In order to investigate their functional …