[HTML][HTML] Progesterone–friend or foe?

I Sundström-Poromaa, E Comasco, R Sumner… - Frontiers in …, 2020 - Elsevier
Estradiol is the “prototypic” sex hormone of women. Yet, women have another sex hormone,
which is often disregarded: Progesterone. The goal of this article is to provide a …

[HTML][HTML] Allopregnanolone in premenstrual dysphoric disorder (PMDD): Evidence for dysregulated sensitivity to GABA-A receptor modulating neuroactive steroids …

L Hantsoo, CN Epperson - Neurobiology of Stress, 2020 - Elsevier
Premenstrual dysphoric disorder (PMDD) is a severe mood disorder with core symptoms
(affective lability, irritability, depressed mood, anxiety) and increased sensitivity to stress …

Towards understanding the biology of premenstrual dysphoric disorder: From genes to GABA

L Hantsoo, JL Payne - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Premenstrual dysphoric disorder (PMDD) is a severe mood disorder, with affective
symptoms that rise and fall in concert with the hormonal fluctuations of the menstrual cycle …

[HTML][HTML] GABAergic signaling by cells of the immune system: more the rule than the exception

AK Bhandage, A Barragan - Cellular and Molecular Life Sciences, 2021 - Springer
Gamma-aminobutyric acid (GABA) is best known as an essential neurotransmitter in the
evolved central nervous system (CNS) of vertebrates. However, GABA antedates the …

[HTML][HTML] GABA regulates release of inflammatory cytokines from peripheral blood mononuclear cells and CD4+ T cells and is immunosuppressive in type 1 diabetes

AK Bhandage, Z Jin, SV Korol, Q Shen, Y Pei… - …, 2018 - thelancet.com
The neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule in
the brain and in pancreatic islets. Here, we demonstrate that GABA regulates cytokine …

[HTML][HTML] The GABA and GABA-receptor system in inflammation, anti-tumor immune responses, and COVID-19

J Tian, DL Kaufman - Biomedicines, 2023 - mdpi.com
GABA and GABAA-receptors (GABAA-Rs) play major roles in neurodevelopment and
neurotransmission in the central nervous system (CNS). There has been a growing …

[HTML][HTML] Allopregnanolone in postpartum depression

G Pinna, FB Almeida, JM Davis - Frontiers in global women's health, 2022 - frontiersin.org
Postpartum depression (PPD) is a debilitating psychiatric disorder characterized by a high
worldwide prevalence and serious long-term negative outcomes for both mothers and …

[HTML][HTML] A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites

AK Bhandage, GC Olivera, S Kanatani, E Thompson… - Elife, 2020 - elifesciences.org
Gamma-aminobutyric acid (GABA) serves diverse biological functions in prokaryotes and
eukaryotes, including neurotransmission in vertebrates. Yet, the role of GABA in the immune …

[HTML][HTML] Allopregnanolone levels and depressive symptoms during pregnancy in relation to single nucleotide polymorphisms in the allopregnanolone synthesis …

C Hellgren, E Comasco, A Skalkidou… - Hormones and …, 2017 - Elsevier
Allopregnanolone, a neurosteroid whose levels rise throughout gestation, putatively
stabilizes antenatal mood. The present study aimed to investigate associations of plasma …

[HTML][HTML] Positive association between dehydroepiandrosterone (DHEA) and gene expression of the gamma-aminobutyric acid (GABA-A) receptor δ subunit

A Hamidovic, S Cho, J Davis - The Journal of Steroid Biochemistry and …, 2024 - Elsevier
Gamma-aminobutyric acid A (GABA-A) receptors in the cells of the immune system enhance
anti-inflammatory responses by regulating cytokine secretion, cytotoxic responses, and cell …