Liposomes are closed bilayer structures spontaneously formed by hydrated phospholipids
that are widely used as efficient delivery systems for drugs or antigens, due to their capability …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Specialized membrane domains are an important feature of almost all cells. In particular,
they are essential to tissues that have a highly organized cell cortex, such as the intestinal …

The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM
(oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are …

A fundamental property of many plasma-membrane proteins is their association with the
underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the
regulation of cell adhesion migration, proliferation and survival. In cancer FAK is a major …

The spectrin-based membrane skeleton of the humble mammalian erythrocyte has provided
biologists with a set of interacting proteins with diverse roles in organization and survival of …

▪ Abstract We review the physical properties of phosphatidylinositol 4, 5-bisphosphate (PIP2)
that determine both its specific interactions with protein domains of known structure and its …

The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

Regulation of integrin affinity (activation) is essential for metazoan development and for
many pathological processes. Binding of the talin phosphotyrosine-binding (PTB) domain to …