The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

[HTML][HTML] Role of lncRNA LUCAT1 in cancer

C Xing, S Sun, ZQ Yue, F Bai - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Long non-coding RNAs (lncRNAs) are RNA molecules with a transcript length of more than
200 nt and lack a protein-coding ability. They regulate gene expression by interacting with …

Non-coding RNAs and their integrated networks

P Zhang, W Wu, Q Chen, M Chen - Journal of integrative …, 2019 - degruyter.com
Eukaryotic genomes are pervasively transcribed. Besides protein-coding RNAs, there are
different types of non-coding RNAs that modulate complex molecular and cellular …

The role of non-coding RNAs in oncology

FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

Noncoding RNA: RNA regulatory networks in cancer

JJ Chan, Y Tay - International journal of molecular sciences, 2018 - mdpi.com
Noncoding RNAs (ncRNAs) constitute the majority of the human transcribed genome. This
largest class of RNA transcripts plays diverse roles in a multitude of cellular processes, and …

Non-coding RNA networks in cancer

E Anastasiadou, LS Jacob, FJ Slack - Nature Reviews Cancer, 2018 - nature.com
Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …

Long non-coding RNAs in the regulation of gene expression: physiology and disease

JCR Fernandes, SM Acuña, JI Aoki, LM Floeter-Winter… - Non-coding RNA, 2019 - mdpi.com
The identification of RNAs that are not translated into proteins was an important
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …

The novel regulatory role of lnc RNA‐mi RNA‐mRNA axis in cardiovascular diseases

Y Huang - Journal of cellular and molecular medicine, 2018 - Wiley Online Library
Long noncoding RNA s (lnc RNA s) are RNA s longer than 200 nt in length that are
characterized by low levels of sequence conservation and expression; lnc RNA s modulate …

Transcriptional and post-transcriptional gene regulation by long non-coding RNA

IM Dykes, C Emanueli - Genomics, Proteomics and …, 2017 - academic.oup.com
Advances in genomics technology over recent years have led to the surprising discovery
that the genome is far more pervasively transcribed than was previously appreciated. Much …

Therapeutic targeting of long non-coding RNAs in cancer

G Arun, SD Diermeier, DL Spector - Trends in molecular medicine, 2018 - cell.com
Long non-coding RNAs (lncRNAs) represent a significant population of the human
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …