The epidemiology of osteoarthritis

VL Johnson, DJ Hunter - Best practice & research Clinical rheumatology, 2014 - Elsevier
Osteoarthritis (OA) is a leading cause of disability and its incidence is rising due to
increasing obesity and an ageing population. Risk factors can be divided into person-level …

[HTML][HTML] Genetic predictors of human chronic pain conditions

K Zorina-Lichtenwalter, CB Meloto, S Khoury… - Neuroscience, 2016 - Elsevier
Chronic pain conditions are multifactorial disorders with a high frequency in the population.
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …

[HTML][HTML] Risk factors and burden of osteoarthritis

C Palazzo, C Nguyen, MM Lefevre-Colau… - Annals of physical and …, 2016 - Elsevier
Osteoarthritis (OA) is one of the most common joint disorders worldwide. Its prevalence is
increasing because of the growing aging of the population in developed and developing …

[HTML][HTML] Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study

arcOGEN Consortium, arcOGEN Collaborators - The Lancet, 2012 - Elsevier
BACKGROUND: Osteoarthritis is the most common form of arthritis worldwide and is a major
cause of pain and disability in elderly people. The health economic burden of osteoarthritis …

Etiology of osteoarthritis: genetics and synovial joint development

LJ Sandell - Nature Reviews Rheumatology, 2012 - nature.com
Osteoarthritis (OA) has a considerable hereditary component and is considered to be a
polygenic disease. Data derived from genetic analyses and genome-wide screening of …

A review of translational animal models for knee osteoarthritis

MH Gregory, N Capito, K Kuroki, AM Stoker, JL Cook… - …, 2012 - Wiley Online Library
Knee osteoarthritis remains a tremendous public health concern, both in terms of health‐
related quality of life and financial burden of disease. Translational research is a critical step …

Occupational and genetic risk factors for osteoarthritis: a review

B Yucesoy, LE Charles, B Baker, CM Burchfiel - Work, 2015 - content.iospress.com
BACKGROUND: Osteoarthritis (OA) is a multifactorial disease with strong genetic and
occupational components. Although published studies have described several risk factors …

Genetic epidemiology of hip and knee osteoarthritis

AM Valdes, TD Spector - Nature Reviews Rheumatology, 2011 - nature.com
Osteoarthritis (OA) is the most common cause of arthritis and represents an enormous
healthcare burden in industrialized societies. Current therapeutic approaches for OA are …

Cartilage biology in osteoarthritis—lessons from developmental biology

AA Pitsillides, F Beier - Nature Reviews Rheumatology, 2011 - nature.com
The cellular and molecular mechanisms responsible for the initiation and progression of
osteoarthritis (OA), and in particular cartilage degeneration in OA, are not completely …

The burden of osteoarthritis: Is it a rising problem?

WJ Scheuing, AM Reginato, M Deeb… - Best Practice & Research …, 2023 - Elsevier
The objective of this review is to provide an overview of the current status of osteoarthritis
(OA) as one of the most common joint disorders worldwide. Despite being the 11th cause of …