High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

A rare and autosomal recessive premature aging disorder, Werner syndrome (WS) is
characterized by the early onset of aging-associated diseases, including shortening stature …

Proliferating cell nuclear antigen (PCNA) is a sliding clamp protein that coordinates DNA
replication with various DNA maintenance events that are critical for human health …

DNA repair genes are critical for preserving genomic stability and it is well established that
mutations in DNA repair genes give rise to progeroid diseases due to perturbations in …

Mammalian DNA replication relies on various DNA helicase and nuclease activities to
ensure accurate genetic duplication, but how different helicase and nuclease activities are …

Characterizing the molecular deficiencies underlying human aging has been a formidable
challenge as it is clear that a complex myriad of factors including genetic mutations …

Multiple myeloma (MM) is a hematologic cancer characterized by accumulation of malignant
plasma cells in the bone marrow. To date, no definitive cure exists for MM and resistance to …

Replication stress refers to slowing or stalling of replication fork progression during DNA
synthesis that disrupts faithful copying of the genome. While long considered a nexus for …

Named the “caretakers” of the genome, RecQ helicases function in several pathways to
maintain genomic stability and repair DNA. This highly conserved family of enzymes consist …

Hereditary breast and ovarian cancers are frequently attributed to germline mutations in the
tumor suppressor genes BRCA1 and BRCA2. BRCA1/2 act to repair double‐strand breaks …