DNA interstrand cross-links (ICLs) are lesions caused by a variety of endogenous
metabolites, environmental exposures, and cancer chemotherapeutic agents that have two …

The maintenance of genome stability is critical for survival, and its failure is often associated
with tumorigenesis. The Fanconi anemia (FA) pathway is essential for the repair of DNA …

Natural-product-derived cytotoxics remain a mainstay in current chemotherapy. 1 This
review focuses on the current level of understanding and emerging trends relevant to the …

Structure-specific endonucleases resolve DNA secondary structures generated during DNA
repair and recombination. The yeast 5′ flap endonuclease Slx1-Slx4 has received …

One of the earliest marks of a double-strand break (DSB) in eukaryotes is serine
phosphorylation of the histone variant H2AX at the carboxy-terminal SQE motif to create …

The importance of platinum drugs in cancer chemotherapy is underscored by the clinical
success of cisplatin [cis-diamminedichloroplatinum (II)] and its analogues and by clinical …

Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …

The cytotoxicity of platinum compounds is thought to be determined primarily by their DNA
adducts. Cisplatin and oxaliplatin are structurally distinct, but form the same types of adducts …

Interstrand DNA crosslinks (ICLs) are formed by natural products of metabolism and by
chemotherapeutic reagents. Work in E. coli identified a two cycle repair scheme involving …

Summary Insulin/IGF-1 signaling (IIS) regulates aging in worms, flies, and mice through a
well-characterized, highly conserved core set of components. IIS also regulates early …