Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment

H Zhao, J Zhang, X Cheng, X Nie, B He - Journal of Ovarian Research, 2023 - Springer
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by
chronic ovulation dysfunction and overabundance of androgens; it affects 6–20% of women …

[HTML][HTML] Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies

MA Sanchez-Garrido, M Tena-Sempere - Molecular metabolism, 2020 - Elsevier
Background Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among
reproductive age women. Although its cardinal manifestations include hyperandrogenism …

Insulin resistance and PCOS: chicken or egg?

P Moghetti, F Tosi - Journal of endocrinological investigation, 2021 - Springer
PCOS is a common and heterogeneous endocrine disorder in women of reproductive age,
frequently associated with metabolic abnormalities. It was estimated that about 75% of these …

[HTML][HTML] Polycystic ovary syndrome and type 2 diabetes mellitus: A state-of-the-art review

S Livadas, P Anagnostis, JK Bosdou… - World journal of …, 2022 - ncbi.nlm.nih.gov
Polycystic ovary syndrome (PCOS) often coexists with a wide spectrum of dysglycemic
conditions, ranging from impaired glucose tolerance to type 2 diabetes mellitus (T2D), which …

Insulin resistance in patients with cancer: a systematic review and meta-analysis

JM Màrmol, M Carlsson, SH Raun, MK Grand… - Acta …, 2023 - Taylor & Francis
Background Insulin resistance is a critical cause of metabolic dysfunctions. Metabolic
dysfunction is common in patients with cancer and is associated with higher cancer …

The role of ceramides in diabetes and cardiovascular disease regulation of ceramides by adipokines

BC Field, R Gordillo, PE Scherer - Frontiers in endocrinology, 2020 - frontiersin.org
Metabolic dysfunction is intertwined with the pathophysiology of both diabetes and
cardiovascular disease. Recently, one particular lipid class has been shown to influence the …

Impact of endurance and resistance training on skeletal muscle glucose metabolism in older adults

LA Consitt, C Dudley, G Saxena - Nutrients, 2019 - mdpi.com
Aging is associated with insulin resistance and the development of type 2 diabetes. While
this process is multifaceted, age-related changes to skeletal muscle are expected to …

Pathophysiology and nutritional approaches in polycystic ovary syndrome (PCOS): a comprehensive review

M Di Lorenzo, N Cacciapuoti, MS Lonardo… - Current Nutrition …, 2023 - Springer
Abstract Purpose of Review Polycystic ovary syndrome (PCOS) is the most common
endocrine and metabolic disorder in women of reproductive age worldwide. This disease …

[HTML][HTML] LNK promotes granulosa cell apoptosis in PCOS via negatively regulating insulin-stimulated AKT-FOXO3 pathway

M Tan, Y Cheng, X Zhong, D Yang, S Jiang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Background: Polycystic ovary syndrome (PCOS), which is often accompanied by insulin
resistance, is closely related to increased apoptosis of ovarian granulosa cells. LNK is an …

Prevalence, risk factors, and pathophysiology of nonalcoholic fatty liver disease (NAFLD) in women with polycystic ovary syndrome (PCOS)

S Spremović Rađenović, M Pupovac, M Andjić, J Bila… - Biomedicines, 2022 - mdpi.com
Abstract Background: Polycystic Ovary Syndrome (PCOS) is one of the most common
endocrine disorders in women's reproductive period of life. The presence of nonalcoholic …