[HTML][HTML] Genome regulation by polycomb and trithorax: 70 years and counting

B Schuettengruber, HM Bourbon, L Di Croce, G Cavalli - Cell, 2017 - cell.com
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

Writing, erasing and reading histone lysine methylations

K Hyun, J Jeon, K Park, J Kim - Experimental & molecular medicine, 2017 - nature.com
Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease

KP Bhat, H Ümit Kaniskan, J Jin… - Nature Reviews Drug …, 2021 - nature.com
Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

Targeting EZH2 in cancer

KH Kim, CWM Roberts - Nature medicine, 2016 - nature.com
Recent genomic studies have resulted in an emerging understanding of the role of
chromatin regulators in the development of cancer. EZH2, a histone methyl transferase …

Histone modifications and cancer

JE Audia, RM Campbell - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

AS Harutyunyan, B Krug, H Chen… - Nature …, 2019 - nature.com
Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly
gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M …

Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a …

A Pastore, V Jurinovic, R Kridel, E Hoster… - The lancet …, 2015 - thelancet.com
Background Follicular lymphoma is a clinically and genetically heterogeneous disease, but
the prognostic value of somatic mutations has not been systematically assessed. We aimed …

Maintaining cell identity: PRC2-mediated regulation of transcription and cancer

I Comet, EM Riising, B Leblanc, K Helin - Nature Reviews Cancer, 2016 - nature.com
Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb repressive
complex 2 (PRC2), has attracted broad research attention in the past few years because of …

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

MT McCabe, HM Ott, G Ganji, S Korenchuk… - Nature, 2012 - nature.com
In eukaryotes, post-translational modification of histones is critical for regulation of chromatin
structure and gene expression. EZH2 is the catalytic subunit of the polycomb repressive …

PRC2 is high maintenance

JR Yu, CH Lee, O Oksuz, JM Stafford… - Genes & …, 2019 - genesdev.cshlp.org
As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …