[HTML][HTML] Genome regulation by polycomb and trithorax: 70 years and counting
B Schuettengruber, HM Bourbon, L Di Croce, G Cavalli - Cell, 2017 - cell.com
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …
modifying factors originally identified as part of an epigenetic cellular memory system that …
Writing, erasing and reading histone lysine methylations
Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …
many cellular events. Lysine methylations mark various sites on the tail and globular …
Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease
Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …
Targeting EZH2 in cancer
KH Kim, CWM Roberts - Nature medicine, 2016 - nature.com
Recent genomic studies have resulted in an emerging understanding of the role of
chromatin regulators in the development of cancer. EZH2, a histone methyl transferase …
chromatin regulators in the development of cancer. EZH2, a histone methyl transferase …
Histone modifications and cancer
JE Audia, RM Campbell - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly
gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M …
gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M …
Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a …
Background Follicular lymphoma is a clinically and genetically heterogeneous disease, but
the prognostic value of somatic mutations has not been systematically assessed. We aimed …
the prognostic value of somatic mutations has not been systematically assessed. We aimed …
Maintaining cell identity: PRC2-mediated regulation of transcription and cancer
Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb repressive
complex 2 (PRC2), has attracted broad research attention in the past few years because of …
complex 2 (PRC2), has attracted broad research attention in the past few years because of …
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
MT McCabe, HM Ott, G Ganji, S Korenchuk… - Nature, 2012 - nature.com
In eukaryotes, post-translational modification of histones is critical for regulation of chromatin
structure and gene expression. EZH2 is the catalytic subunit of the polycomb repressive …
structure and gene expression. EZH2 is the catalytic subunit of the polycomb repressive …
PRC2 is high maintenance
As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …