Uric acid (UA), scavenger of oxygen radical, is a very important antioxidant that help
maintains the stability of blood pressure and antioxidant stress. However, an abnormal UA …

The human solute carrier 22 family (SLC22), also termed the organic ion transporter family,
consists of 28 distinct multi-membrane spanning proteins, which phylogenetically cluster …

Hypouricemia is recognized as a rare disorder, defined as a serum uric acid level of 2.0
mg/dL or less. Hypouricemia is divided into an overexcretion type and an underproduction …

In observational studies, high serum urate levels are associated with adverse outcomes,
including mortality. However, the hypothesis that urate-lowering may improve nongout …

Background Hereditary renal hypouricemia type 1 (RHUC1) is caused by
URAT1/SLC22A12 dysfunction, resulting in urolithiasis and exercise-induced AKI (EIAKI) …

Gout is a common arthritis caused by monosodium urate crystals. The heritability of serum
urate levels is estimated to be 30–70%; however, common genetic variants account for only …

Uric acid (UA) is the end-product in the human purine metabolism pathway. The UA that
accumulates in silkworm tissues is excreted as a nitrogen waste product. Here, we first …

Chemical sensors for the determination of uric acid (UA) in human urine samples have been
developed using a composite material based on two core–shells (Ag2S@-and Bi2S3@-) …

Hypouricemia is defined as a level of serum uric acid below 2 mg/dl. Renal hypouricemia is
related to genetic defects of the uric acid tubular transporters urate transporter 1 and glucose …

Background/aims Familial juvenile hereditary nephropathy (FJHN) is characterized by
hyperuricemia due to severely impaired urinary excretion of urate. Hereditary renal …