The impact of circadian rhythms on cardiovascular function and disease development is well
established, with numerous studies in genetically modified animals emphasizing the …

The impact of the coronavirus disease 2019 (COVID-19) pandemic on the global economy is
far-reaching and difficult to assess accurately. We aimed to systematically determine the …

Background Critical illness is a state of ill health with vital organ dysfunction, a high risk of
imminent death if care is not provided and potential for reversibility. The burden of critical …

Background The aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio
has been shown to be associated with poor clinical outcomes across various patient groups …

Purpose To report two-year survival after scheduled extubation in patients with pneumonia
or acute respiratory distress syndrome (ARDS). Methods This was a prospective …

Objectives: To date, age, frailty, and multimorbidity have been used primarily to inform
prognosis in older adults. It remains uncertain, however, whether these patient factors may …

The rapidly advancing field of cancer therapeutics has led to increased longevity among
cancer patients as well as increasing complexity of cancer-related illness and associated …

Objectives The intensive care unit (ICU) mortality rate remains high especially in developing
countries regardless of the advances in critical management. There is a lack of studies about …

Objective As calculated by the severity scores, an unknown number of patients are admitted
to the Intensive Care Unit (ICU) with a very high risk of death. Clinical studies have poorly …

Background Age is a significant consideration for intensive care unit (ICU) admission.
However, the reported associations between increasing age and mortality vary across …