The GABA excitatory/inhibitory shift in brain maturation and neurological disorders
Y Ben-Ari, I Khalilov, KT Kahle… - The …, 2012 - journals.sagepub.com
Ionic currents and the network-driven patterns they generate differ in immature and adult
neurons: The developing brain is not a “small adult brain.” One of the most investigated …
neurons: The developing brain is not a “small adult brain.” One of the most investigated …
[HTML][HTML] The GABA excitatory/inhibitory developmental sequence: a personal journey
Y Ben-Ari - Neuroscience, 2014 - Elsevier
The developing brain is talkative but its language is not that of the adult. Most if not all
voltage and transmitter-gated ionic currents follow a developmental sequence and network …
voltage and transmitter-gated ionic currents follow a developmental sequence and network …
[HTML][HTML] GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo
K Kirmse, M Kummer, Y Kovalchuk, OW Witte… - Nature …, 2015 - nature.com
A large body of evidence from in vitro studies suggests that GABA is depolarizing during
early postnatal development. However, the mode of GABA action in the intact developing …
early postnatal development. However, the mode of GABA action in the intact developing …
Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments
In cortical and hippocampal neurons, cation-chloride cotransporters (CCCs) control the
reversal potential (EGABA) of GABAA receptor-mediated current and voltage responses …
reversal potential (EGABA) of GABAA receptor-mediated current and voltage responses …
Ketone bodies in epilepsy
MA McNally, AL Hartman - Journal of neurochemistry, 2012 - Wiley Online Library
J. Neurochem.(2012) 121, 28–35. Abstract Seizures that are resistant to standard
medications remain a major clinical problem. One underutilized option for patients with …
medications remain a major clinical problem. One underutilized option for patients with …
[HTML][HTML] Mechanisms of ketogenic diet action
SA Masino, JM Rho - Jasper's Basic Mechanisms of the Epilepsies …, 2012 - ncbi.nlm.nih.gov
Within the past two decades, interest in understanding the therapeutic mechanisms of
ketogenic diet (KD) action has grown steadily. Expanded knowledge about underlying …
ketogenic diet (KD) action has grown steadily. Expanded knowledge about underlying …
Neurotoxicity of anesthetic drugs in the developing brain
G Stratmann - Anesthesia & Analgesia, 2011 - journals.lww.com
Anesthesia kills neurons in the brain of infantile animals, including primates, and causes
permanent and progressive neurocognitive decline. The anesthesia community and …
permanent and progressive neurocognitive decline. The anesthesia community and …
[HTML][HTML] Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!
During brain development, there is a progressive reduction of intracellular chloride
associated with a shift in GABA polarity: GABA depolarizes and occasionally excites …
associated with a shift in GABA polarity: GABA depolarizes and occasionally excites …
[HTML][HTML] KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
Although cortical interneurons are apparently well-placed to suppress seizures, several
recent reports have highlighted a paradoxical role of perisomatic-targeting parvalbumin …
recent reports have highlighted a paradoxical role of perisomatic-targeting parvalbumin …
[HTML][HTML] Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis
Chloride homeostasis is a critical determinant of the strength and robustness of inhibition
mediated by GABAA receptors (GABAARs). The impact of changes in steady state Cl …
mediated by GABAA receptors (GABAARs). The impact of changes in steady state Cl …