Peptide-based cancer therapy: opportunity and challenge
D Wu, Y Gao, Y Qi, L Chen, Y Ma, Y Li - Cancer letters, 2014 - Elsevier
Cancer is one of the leading causes of death worldwide. Conventional cancer therapies
mainly focus on mass cell killing without high specificity and often cause severe side effects …
mainly focus on mass cell killing without high specificity and often cause severe side effects …
Tumor-targeting peptides from combinatorial libraries
Cancer is one of the major and leading causes of death worldwide. Two of the greatest
challenges in fighting cancer are early detection and effective treatments with no or …
challenges in fighting cancer are early detection and effective treatments with no or …
Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification
B Meeusen, V Janssens - The international journal of biochemistry & cell …, 2018 - Elsevier
Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …
Approaches to study phosphatases
Phosphatases play key roles in normal physiology and diseases. Studying phosphatases
has been both essential and challenging, and the application of conventional genetic and …
has been both essential and challenging, and the application of conventional genetic and …
Challenges and opportunities in the development of protein phosphatase-directed therapeutics
Protein phosphatases have both protective and promoting roles in the etiology of diseases.
A prominent example is the existence of oncogenic as well as tumor-suppressing protein …
A prominent example is the existence of oncogenic as well as tumor-suppressing protein …
Receptor-type protein tyrosine phosphatases in cancer
Y Du, JR Grandis - Chinese journal of cancer, 2015 - Springer
Protein tyrosine phosphatases (PTPs) play an important role in regulating cell signaling
events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival …
events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival …
Genetic alterations of protein tyrosine phosphatases in human cancers
S Zhao, D Sedwick, Z Wang - Oncogene, 2015 - nature.com
Protein tyrosine phosphatases (PTPs) are enzymes that remove phosphate from tyrosine
residues in proteins. Recent whole-exome sequencing of human cancer genomes reveals …
residues in proteins. Recent whole-exome sequencing of human cancer genomes reveals …
The structure, function and regulation of protein tyrosine phosphatase receptor type J and its role in diseases
H Li, P Zhang, C Liu, Y Wang, Y Deng, W Dong, Y Yu - Cells, 2022 - mdpi.com
Protein tyrosine phosphatase receptor type J (PTPRJ), also known as DEP-1, HPTPη, or
CD148, belongs to the R3 subfamily of receptor protein tyrosine phosphatases (RPTPs). It …
CD148, belongs to the R3 subfamily of receptor protein tyrosine phosphatases (RPTPs). It …
Antioxidative peptides: Trends and perspectives for future research
AC Freitas, JC Andrade, FM Silva… - Current medicinal …, 2013 - ingentaconnect.com
In recent years, much attention has been given to dietary antioxidants, especially
polyphenols. Several peptides derived from protein molecules have also been found to …
polyphenols. Several peptides derived from protein molecules have also been found to …
T-cell leukemia/lymphoma 1 (TCL1): an oncogene regulating multiple signaling pathways
Almost 30 years ago, Carlo Croce's group discovered the T-Cell Leukemia/Lymphoma 1A
oncogene (TCL1A or TCL1). TCL1 protein is normally expressed in fetal tissues and early …
oncogene (TCL1A or TCL1). TCL1 protein is normally expressed in fetal tissues and early …