The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Adipose tissue is a major source of energy for the human body. It is also a source of major
adipocytokines adiponectin and leptin. Insulin resistance is a condition in which insulin …

Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

▪ Abstract The discovery of the adipose-derived hormone leptin has generated enormous
interest in the interaction between peripheral signals and brain targets involved in the …

Following the discovery of leptin in 1994, the scientific and clinical communities have held
great hope that manipulation of the leptin axis may lead to the successful treatment of …

Leptin is a versatile 16 kDa peptide hormone, with a tertiary structure resembling that of
members of the long-chain helical cytokine family. It is mainly produced by adipocytes in …

The brain controls energy homeostasis and body weight by integrating various metabolic
signals. Leptin, an adipose-derived hormone, conveys critical information about peripheral …

The discovery of leptin in 1994 has led to astonishing advances in understanding the
regulation of energy balance in rodents and humans. The demonstration of leptin receptors …

Leptin is currently believed to control body composition largely, if not entirely, via
hypothalamic receptors that regulate food intake and thermogenesis. Here we demonstrate …

The mechanisms involved in body weight regulation in humans include genetic,
physiological, and behavioral factors. Stability of body weight and body composition …