[HTML][HTML] Gut microbiome and health: mechanistic insights

WM De Vos, H Tilg, M Van Hul, PD Cani - Gut, 2022 - gut.bmj.com
The gut microbiota is now considered as one of the key elements contributing to the
regulation of host health. Virtually all our body sites are colonised by microbes suggesting …

Gut microbiota in human metabolic health and disease

Y Fan, O Pedersen - Nature Reviews Microbiology, 2021 - nature.com
Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …

[HTML][HTML] Rethinking healthy eating in light of the gut microbiome

AM Armet, EC Deehan, AF O'Sullivan, JF Mota… - Cell Host & Microbe, 2022 - cell.com
Given the worldwide epidemic of diet-related chronic diseases, evidence-based dietary
recommendations are fundamentally important for health promotion. Despite the importance …

Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options

C Grander, F Grabherr, H Tilg - Cardiovascular Research, 2023 - academic.oup.com
The prevalence of non-alcoholic fatty liver disease (NAFLD) is continually increasing due to
the global obesity epidemic. NAFLD comprises a systemic metabolic disease accompanied …

Interplay between diet, the gut microbiome, and atherosclerosis: Role of dysbiosis and microbial metabolites on inflammation and disordered lipid metabolism

L Anto, CN Blesso - The Journal of Nutritional Biochemistry, 2022 - Elsevier
Atherosclerosis remains the leading cause of death worldwide. Lifestyle modification,
including diet and exercise, is recommended to be the primary prevention strategy for …

Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis

M Witkowski, M Witkowski, J Friebel… - Cardiovascular …, 2022 - academic.oup.com
Aims Gut microbiota and their generated metabolites impact the host vascular phenotype.
The metaorganismal metabolite trimethylamine N-oxide (TMAO) is both associated with …

[HTML][HTML] Propionate alleviates myocardial ischemia-reperfusion injury aggravated by angiotensin II dependent on caveolin-1/ACE2 axis through GPR41

F Deng, LQ Zhang, H Wu, Y Chen, WQ Yu… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Myocardial ischemia/reperfusion (I/R) injury is still a lack of effective therapeutic drugs, and
its molecular mechanism is urgently needed. Studies have shown that the intestinal flora …

Contribution of the microbiome for better phenotyping of people living with obesity

A Di Ciaula, L Bonfrate, M Khalil, G Garruti… - Reviews in Endocrine …, 2023 - Springer
Obesity has reached epidemic proportion worldwide and in all ages. Available evidence
points to a multifactorial pathogenesis involving gene predisposition and environmental …

Lycium barbarum polysaccharide attenuates myocardial injury in high-fat diet-fed mice through manipulating the gut microbiome and fecal metabolome

Z Zhang, H Liu, B Yu, H Tao, J Li, Z Wu, G Liu… - Food Research …, 2020 - Elsevier
High-fat diets (HFDs) can induce health problems including gut microbiota dysbiosis and
cardiac dysfunction. In this study, we modulated the gut microbiota in mice to investigate …

Gut metabolite trimethylamine-N-oxide in atherosclerosis: from mechanism to therapy

BY Wang, J Qiu, JF Lian, X Yang… - Frontiers in cardiovascular …, 2021 - frontiersin.org
Atherosclerosis is associated with various pathological manifestations, such as ischemic
heart disease, ischemic stroke, and peripheral arterial disease, and remains a leading …