[HTML][HTML] Diabetes mellitus and diabetic foot ulcer: Etiology, biochemical and molecular based treatment strategies via gene and nanotherapy

AVA Mariadoss, AS Sivakumar, CH Lee… - Biomedicine & …, 2022 - Elsevier
Diabetes mellitus (DM) is a collection of metabolic and pathophysiological disorders
manifested with high glucose levels in the blood due to the inability of β-pancreatic cells to …

How many chemicals in commerce have been analyzed in environmental media? A 50 year bibliometric analysis

DCG Muir, GJ Getzinger, M McBride… - … Science & Technology, 2023 - ACS Publications
Over the past 50 years, there has been a tremendous expansion in the measurement of
chemical contaminants in environmental media. But how many chemicals have actually …

Therapeutic potential and pharmaceutical development of a multitargeted flavonoid phloretin

KT Nakhate, H Badwaik, R Choudhary, K Sakure… - Nutrients, 2022 - mdpi.com
Phloretin is a flavonoid of the dihydrogen chalcone class, present abundantly in apples and
strawberries. The beneficial effects of phloretin are mainly associated with its potent …

Comparison of non-covalent binding interactions between three whey proteins and chlorogenic acid: Spectroscopic analysis and molecular docking

Y Zhang, Y Lu, Y Yang, S Li, C Wang, C Wang… - Food Bioscience, 2021 - Elsevier
Non-covalent binding interactions between three whey proteins β-lactoglobulin (β-Lg), α-
lactalbumin (α-La) and bovine serum albumin (BSA) with chlorogenic acid (CA) were …

A systematic review of synthetic tyrosinase inhibitors and their structure-activity relationship

Z Peng, G Wang, QH Zeng, Y Li, H Liu… - Critical Reviews in …, 2022 - Taylor & Francis
Tyrosinase is a copper-containing oxidation enzyme, which is responsible for the production
of melanin. This enzyme is widely distributed in microorganisms, animals and plants, and …

Geminal diheteroatomic motifs: some applications of acetals, ketals, and their sulfur and nitrogen homologues in medicinal chemistry and drug design

YJ Wu, NA Meanwell - Journal of Medicinal Chemistry, 2021 - ACS Publications
Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction

L Jiaqi, H Siqing - Phytomedicine, 2023 - Elsevier
Background Ferroptosis, a form of regulated cell death by lipid peroxidation, was currently
considered as a key factor affecting the occurrence and progression in various cancers …

Dermatological applications of the flavonoid phloretin

TPA Casarini, LA Frank, AR Pohlmann… - European journal of …, 2020 - Elsevier
Botanical molecules are known to have the ability to counteract ultraviolet radiation-induced
skin damage. The interest in the development of natural compound-based products for the …

Isolinderalactone sensitizes oxaliplatin-resistance colorectal cancer cells through JNK/p38 MAPK signaling pathways

AW Kwak, JW Park, SO Lee, JY Lee, J Seo, G Yoon… - Phytomedicine, 2022 - Elsevier
Background Isolinderalactone (ILL), a sesquiterpene lactone compound, can be extracted
from the root of Lindera aggregate. Physiological activities of ILL, including anti-inflammatory …

Untargeted Metabolomic Profiling and Antioxidant Capacities of Different Solvent Crude Extracts of Ephedra foeminea

R Al-Nemi, AA Makki, K Sawalha, D Hajjar, M Jaremko - Metabolites, 2022 - mdpi.com
Ephedra foeminea is a traditional medicinal plant used in the Eastern Mediterranean region.
This study aims to investigate the chemical profiles of different solvent extracts of E …