PURPOSE: To revise the staging system for cutaneous melanoma under the auspices of the
American Joint Committee on Cancer (AJCC). MATERIALS AND METHODS: The prognostic …

The current (seventh) edition of the American Joint Commission on Cancer (AJCC) staging
system for melanoma is now approaching its sixth year since publication and is based on …

PURPOSE: The American Joint Committee on Cancer (AJCC) recently proposed major
revisions of the tumor-node-metastases (TNM) categories and stage groupings for …

Abstract Purpose: Interferon (IFN)-α2b is the only Food and Drug Administration–approved
treatment for operable high-risk melanoma that has been shown to significantly and durably …

Background: Historically, patients with thick (≥ 4 mm) primary melanoma have not been
considered candidates for elective lymph node dissection, because their risk for occult …

Background: Melanoma is a malignant neoplasia that shows high mortality when diagnosed
in advanced stages. Early identification of high-risk patients for the development of …

Background The overall prognosis of patients with thick cutaneous melanoma (TCM) is
generally thought to be poor. Surgically staging these patients with sentinel lymph node …

Since the 1960s, the clinical characteristics of melanoma, its histopathology and its
biological basis have been the subject of intense study at pigmented lesion clinics in North …

Background Although sentinel node biopsy (SNB) has become standard of care in patients
with melanoma, its use in patients with thin or thick melanomas remains a matter of debate …

Significant prognostic information is available in a routine melanoma dermatopathology
report. Features that are enumerated in the pathology report and that portend a potentially …